Open AccessBook
Biotransformations in Organic Chemistry
Kurt Faber
- 01 Jan 1992
TL;DR: This professional referencebook on Biotransformations in organic Chemistry is aimed at graduate students in Organic Chemistry and Biotechnology, scientists and professionals who want to use the powerful synthetic tool of enzymes for modern preparative organic chemistry.
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Abstract: The use of biocatalysts as enzymes and/or whole cells, offers a remarkable arsenal of highly selective transformations in preparative organic chemistry. A large number of synthetically useful reactions can be catalysed by enzymes in a highly selective manner. This book pinpoints the chemo-, regio- and stereoselective transformations which have been shown to be most useful as an alternative to the already existing methods for stereoselective synthesis. The types of reaction covered inter alia are: hydrolysis-condensation, redox-reactions, addition-elimination, carbon-carbon bond formation, halogenation, etc. Special techniques, such as enzyme-immobilization and the use of biocatalysts in organic solvents are introduced to the newcomer. This is the first approach to provide a condensed introduction into this field written from the viewpoint of an organic chemist. This professional referencebook on Biotransformations in Organic Chemistry is aimed at graduate students in Organic Chemistry and Biotechnology, scientists and professionals who want to use the powerful synthetic tool of enzymes for modern preparative organic chemistry.
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Citations
Synthesis of ethyl (R)-mandelate using recombinant Carboxydothermus hydrogenoformans alcohol dehydrogenase produced by two yeast species
Jakub Kasprzak,Marion Rauter,Sylvia Denter,Karin Becker,Kim Baronian,Rüdiger Bode,Frieder Schauer,Michael Piontek,H.-Matthias Vorbrodt,Gotthard Kunze +9 more
TL;DR: Comparison of purified recombinant ChADH/BmGDH and both of the yeast cell based catalysts ability to synthesize ethyl ( R )-mandelate demonstrated that Hansenula polymorpha cell catalysts were able to produce the highest yield.
5
Enantio- and diastereoselective acylation of prochiral hydroxyl group of pyrimidine acyclonucleosides
TL;DR: The lipase BCL enabled desymmetrization of pro-R hydroxyl groups and gave (2R)-monoesters and absolute configuration of the products was confirmed by means of ECD spectroscopy supported by theoretical calculations.
5
Biotransformation of Ethinylestradiol by Whole Cells of Brazilian Marine-Derived Fungus Penicillium oxalicum CBMAI 1996.
TL;DR: A biotransformation pathway of ethinylestradiol 1 is proposed, which suggests the presence of several enzymes such as phenol oxidases, monooxygenases, and ene-reductases in the fungus P. oxalicum CBMAI 1996.
5
Sustainable Enzymatic Approach for the Production of Essential Fatty Acid Based on Coffee Oil Hydrolysis
André José Fernandes,Eduardo Henrique Bredda,Patrícia Caroline Molgero Da Rós,Ernandes Benedito Pereira +3 more
TL;DR: In this paper, the physicochemical properties and fatty acid profile of coffee oil were determined and the best predicted concentrations of lipase and gum Arabic were 0.1 and 1.5 wt%, respectively.
5
References
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Biocatalysis in Organic Media
L.E.S. Brink,Johannes Tramper,K. Ch. A. M. Luyben,K. van 't Riet +3 more
- 01 Jun 1987
TL;DR: The epoxidation of alkenes in water/solvent two-phase systems is discussed to give an example of the scope of biotechnological processes that is obtained by using organic media.
596
Enzymes in organic synthesis-29 : Preparations of enantiomerically pure cis -2,3- and 2,4-dimethyl lactones via horse liver alcohol dehydrogenase-catalyzed oxidations☆☆☆
TL;DR: In this paper, the broad applicability of horse liver alcohol dehydrogenase-catalyzed oxidations of meso-diols as a route to chiral lactones of asymmetric synthetic value is described.
325
Biocatalysis in agricultural biotechnology
John R. Whitaker,Philip E. Sonnet +1 more
- 01 Jan 1989
TL;DR: That's it, a book to wait for in this month for releasing this book biocatalysis in agricultural biotechnology; you may not be able to get in some stress, so don't go around and seek fro the book until you really get it.
185
•Book
Biocatalysis: From Discovery to Application
Wolf-Dieter Fessner
- 15 Mar 2000
TL;DR: The present work focused on the development of biocatalytic Approaches for the Synthesis of Enantiopure Epoxides with a focus on the components of the E. coli Oligosaccharides.
155