Open AccessBook
Biotransformations in Organic Chemistry
Kurt Faber
- 01 Jan 1992
TL;DR: This professional referencebook on Biotransformations in organic Chemistry is aimed at graduate students in Organic Chemistry and Biotechnology, scientists and professionals who want to use the powerful synthetic tool of enzymes for modern preparative organic chemistry.
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Abstract: The use of biocatalysts as enzymes and/or whole cells, offers a remarkable arsenal of highly selective transformations in preparative organic chemistry. A large number of synthetically useful reactions can be catalysed by enzymes in a highly selective manner. This book pinpoints the chemo-, regio- and stereoselective transformations which have been shown to be most useful as an alternative to the already existing methods for stereoselective synthesis. The types of reaction covered inter alia are: hydrolysis-condensation, redox-reactions, addition-elimination, carbon-carbon bond formation, halogenation, etc. Special techniques, such as enzyme-immobilization and the use of biocatalysts in organic solvents are introduced to the newcomer. This is the first approach to provide a condensed introduction into this field written from the viewpoint of an organic chemist. This professional referencebook on Biotransformations in Organic Chemistry is aimed at graduate students in Organic Chemistry and Biotechnology, scientists and professionals who want to use the powerful synthetic tool of enzymes for modern preparative organic chemistry.
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Citations
Candida antarctica lipase B-mediated regioselective acylation of dihydroxybenzenes in organic solvents
TL;DR: Candida antarctica lipase B proved to be a highly active biocatalyst for the direct acylation of phenolic hydroxy groups of substituted hydroquinones and resorcinols, which have rarely been reported so far.
10
Separation of cis/trans-cyclohexanecarboxylates by enzymatic hydrolysis: Preference for diequatorial isomers
TL;DR: In this article, cyclohexanecarboxylates were separated into the isomers by enzymatic hydrolysis with lipase from Candida rugosa with very good selectivity.
10
Candida zeylanoides as whole-cell biocatalyst to perform asymmetric bioreduction of benzophenone derivatives
TL;DR: This yeast biocatalyst successfully applied bioreduction of structurally bulky prochiral substrates, which cannot be reducted by chemical catalysis, which demonstrates an encouraging green chemistry approach for the production of biaryl secondary chiral alcohols of pharmaceutical importance in mild, inexpensive and environmentally friendly process.
10
A rational approach to the regioselective deacetylation of 2′,3′,5′-tri-O-acetyluridine by Novozym 435 catalysed alcoholysis
TL;DR: Simple molecular modelling analysis supports that key O/H atoms from TAU and the resulting intermediates display the adequate distances to generate productive binding only when the inverse coordination of TAU is present through the 5'-moiety ofTAU, at high ethanol concentrations.
10
Zinc(II)-mediated diastereoselective Passerini reactions of biocatalytically desymmetrised renewable inputs
Lisa Moni,Luca Banfi,Daniele Cartagenova,Andrea Cavalli,Andrea Cavalli,Chiara Lambruschini,Elisa Martino,Romano V. A. Orru,Eelco Ruijter,Jordy M. Saya,Jacopo Sgrignani,Jacopo Sgrignani,Renata Riva +12 more
TL;DR: 2,5-Bis(hydroxymethyl)tetrahydrofuran, a renewable building block, has been efficiently desymmetrised to give either enantiomers of the corresponding monobutyrate in high ee exploiting a biocatalytic methodology.
10
References
•Book
Biocatalysis in Organic Media
L.E.S. Brink,Johannes Tramper,K. Ch. A. M. Luyben,K. van 't Riet +3 more
- 01 Jun 1987
TL;DR: The epoxidation of alkenes in water/solvent two-phase systems is discussed to give an example of the scope of biotechnological processes that is obtained by using organic media.
596
Enzymes in organic synthesis-29 : Preparations of enantiomerically pure cis -2,3- and 2,4-dimethyl lactones via horse liver alcohol dehydrogenase-catalyzed oxidations☆☆☆
TL;DR: In this paper, the broad applicability of horse liver alcohol dehydrogenase-catalyzed oxidations of meso-diols as a route to chiral lactones of asymmetric synthetic value is described.
325
Biocatalysis in agricultural biotechnology
John R. Whitaker,Philip E. Sonnet +1 more
- 01 Jan 1989
TL;DR: That's it, a book to wait for in this month for releasing this book biocatalysis in agricultural biotechnology; you may not be able to get in some stress, so don't go around and seek fro the book until you really get it.
185
•Book
Biocatalysis: From Discovery to Application
Wolf-Dieter Fessner
- 15 Mar 2000
TL;DR: The present work focused on the development of biocatalytic Approaches for the Synthesis of Enantiopure Epoxides with a focus on the components of the E. coli Oligosaccharides.
155