Open AccessBook
Biotransformations in Organic Chemistry
Kurt Faber
- 01 Jan 1992
TL;DR: This professional referencebook on Biotransformations in organic Chemistry is aimed at graduate students in Organic Chemistry and Biotechnology, scientists and professionals who want to use the powerful synthetic tool of enzymes for modern preparative organic chemistry.
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Abstract: The use of biocatalysts as enzymes and/or whole cells, offers a remarkable arsenal of highly selective transformations in preparative organic chemistry. A large number of synthetically useful reactions can be catalysed by enzymes in a highly selective manner. This book pinpoints the chemo-, regio- and stereoselective transformations which have been shown to be most useful as an alternative to the already existing methods for stereoselective synthesis. The types of reaction covered inter alia are: hydrolysis-condensation, redox-reactions, addition-elimination, carbon-carbon bond formation, halogenation, etc. Special techniques, such as enzyme-immobilization and the use of biocatalysts in organic solvents are introduced to the newcomer. This is the first approach to provide a condensed introduction into this field written from the viewpoint of an organic chemist. This professional referencebook on Biotransformations in Organic Chemistry is aimed at graduate students in Organic Chemistry and Biotechnology, scientists and professionals who want to use the powerful synthetic tool of enzymes for modern preparative organic chemistry.
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Citations
Molecular cloning of enantioselective ester hydrolase from Bacillus pumilus DBRL-191.
Shafaq Rasool,Sarojini Johri,Syed Riyaz-Ul-Hassan,Qurrat-ul-Ain Maqbool,Vijeshwar Verma,Surrinder Koul,Subhash C. Taneja,Ghulam Nabi Qazi +7 more
TL;DR: 3-D the structural model of the enzyme built by homology modelling using the atomic coordinates from the crystal structure of B. subtilis lipase (LipA) showed a compact minimal alpha/beta hydrolase fold.
20
Synthesis of amidrazones using an engineered papain nitrile hydratase1
TL;DR: Compared to wild‐type enzyme, the engineered nitrile hydratase causes a better than 4000‐fold increase in the rate of amidrazone formation and yields a product of much higher purity.
20
Understanding and engineering the enantioselectivity of candida antarctica lipase b towards sec-alcohols
Didier Rotticci
- 01 Jan 2000
TL;DR: Understanding and engineering the enantioselectivity of candida antarctica lipase b towards sec-alcohols and its applications in biochemistry and materials science.
Enhanced performance of lipase-catalyzed kinetic resolution of secondary alcohols in monoether-functionalized ionic liquids.
TL;DR: MEF-ILs can be a new class of enzyme-benign media suitable for lipase-catalyzed kinetic resolution of secondary alcohols and have been found to contribute to the increased enantioselectivity and enhancement of the reaction rate.
20
References
•Book
Biocatalysis in Organic Media
L.E.S. Brink,Johannes Tramper,K. Ch. A. M. Luyben,K. van 't Riet +3 more
- 01 Jun 1987
TL;DR: The epoxidation of alkenes in water/solvent two-phase systems is discussed to give an example of the scope of biotechnological processes that is obtained by using organic media.
596
Enzymes in organic synthesis-29 : Preparations of enantiomerically pure cis -2,3- and 2,4-dimethyl lactones via horse liver alcohol dehydrogenase-catalyzed oxidations☆☆☆
TL;DR: In this paper, the broad applicability of horse liver alcohol dehydrogenase-catalyzed oxidations of meso-diols as a route to chiral lactones of asymmetric synthetic value is described.
325
Biocatalysis in agricultural biotechnology
John R. Whitaker,Philip E. Sonnet +1 more
- 01 Jan 1989
TL;DR: That's it, a book to wait for in this month for releasing this book biocatalysis in agricultural biotechnology; you may not be able to get in some stress, so don't go around and seek fro the book until you really get it.
185
•Book
Biocatalysis: From Discovery to Application
Wolf-Dieter Fessner
- 15 Mar 2000
TL;DR: The present work focused on the development of biocatalytic Approaches for the Synthesis of Enantiopure Epoxides with a focus on the components of the E. coli Oligosaccharides.
155