Biosensors based on electrochemical lactate detection: A comprehensive review
TL;DR: A comparative study to summarize the L-lactate biosensors on the basis of different analytical properties in terms of fabrication, sensitivity, detection limit, linearity, response time and storage stability has been done.
read more
Abstract: Lactate detection plays a significant role in healthcare, food industries and is specially necessitated in conditions like hemorrhage, respiratory failure, hepatic disease, sepsis and tissue hypoxia. Conventional methods for lactate determination are not accurate and fast so this accelerated the need of sensitive biosensors for high-throughput screening of lactate in different samples. This review focuses on applications and developments of various electrochemical biosensors based on lactate detection as lactate being essential metabolite in anaerobic metabolic pathway. A comparative study to summarize the L-lactate biosensors on the basis of different analytical properties in terms of fabrication, sensitivity, detection limit, linearity, response time and storage stability has been done. It also addresses the merits and demerits of current enzyme based lactate biosensors. Lactate biosensors are of two main types - lactate oxidase (LOD) and lactate dehydrogenase (LDH) based. Different supports tried for manufacturing lactate biosensors include membranes, polymeric matrices-conducting or non-conducting, transparent gel matrix, hydrogel supports, screen printed electrodes and nanoparticles. All the examples in these support categories have been aptly discussed. Finally this review encompasses the conclusion and future emerging prospects of lactate sensors.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
Wearable sweat sensors
Mallika Bariya,Mallika Bariya,Hnin Yin Yin Nyein,Hnin Yin Yin Nyein,Ali Javey,Ali Javey +5 more
- 01 Mar 2018
TL;DR: The development of wearable sweat sensors is examined, considering the challenges and opportunities for such technology in the context of personalized healthcare and the requirements of the underlying components.
Direct metabolite detection with an n-type accumulation mode organic electrochemical transistor.
Anna-Maria Pappa,Anna-Maria Pappa,David Ohayon,Alexander Giovannitti,Iuliana P. Maria,Achilleas Savva,Ilke Uguz,Jonathan Rivnay,Iain McCulloch,Iain McCulloch,Róisín M. Owens,Róisín M. Owens,Sahika Inal +12 more
TL;DR: The combination of redox enzymes and electron-transporting polymers will open up an avenue not only for the field of biosensors but also for the development of enzyme-based electrocatalytic energy generation/storage devices.
223
Microneedle-based biosensor for minimally-invasive lactate detection.
TL;DR: The first mediated microneedle-based biosensor for minimally invasive continuous sensing of lactate in the dermal interstitial fluid (ISF) is reported and holds interesting promise for the development of a real-time monitoring device to be used in sport medicine and clinical care.
203
Enzyme based amperometric biosensors
Paolo Bollella,Lo Gorton +1 more
TL;DR: Current research on enzyme based electrochemical biosensors deals essentially with the same target analytes as was at focus in the early days of biosensor research, that is those within the clinical/medical, food/agriculture, and environmental fields.
189
Wearable Technology for Chronic Wound Monitoring: Current Dressings, Advancements, and Future Prospects.
TL;DR: Improvements in materials, platforms, fabrication methods for wearable devices, and quantitative analysis of various biomarkers vital to wound healing progress are focused on.
References
Development and validation of the high performance liquid chromatography-ion exclusion method for detection of lactic acid in milk.
Maria Patrícia Milagres,Sebastião César Cardoso Brandão,Mirella Araujo Magalhães,Valéria Paula Rodrigues Minim,Luis Antonio Minim +4 more
TL;DR: The proposed analytical method for lactic acid quantification in milk by ion exclusion-HPLC with UV detection proved to be a useful quality control tool in laboratories because it was able to determine milk acidity even in adulterated samples.
42
Reagentless amperometric detection of l-lactate on an enzyme-modified conducting copolymer poly(5-hydroxy-1,4-naphthoquinone-co-5-hydroxy-3-thioacetic acid-1,4-naphthoquinone).
TL;DR: A reagentless lactate sensor is constructed using lactate oxidase (LOD) covalently attached to an electropolymerized copolymer film, poly(5-hydroxy-1,4-naphthoquinone-co-5-Hydroxy-3-thioacetic acid-1-4- naphthOquinone), poly(JUG- co-JUGA).
42
Electrochemical characteristics of a carbon-based thick-film l-lactate biosensor using l-lactate dehydrogenase
Hyun C. Yoon,Hak-Sung Kim +1 more
TL;DR: In this article, carbon-based thick-film electrodes employing nicotinamide adenine dinucleotide (NAD+)-dependent dehydrogenases were constructed by screen printing cyclic voltammetric and amperometric investigations of the carbon electrode showed significantly different electrocatalytic properties toward NADH compared to conventional polished electrodes.
41
Lactate biosensor based on a bionanocomposite composed of titanium oxide nanoparticles, photocatalytically reduced graphene, and lactate oxidase
Elena Casero,Concepción Alonso,María Dolores Petit-Domínguez,Luis Vázquez,A. M. Parra-Alfambra,Pablo Merino,S. Álvarez-García,Alicia de Andrés,Edna Suárez,Félix Pariente,Encarnación Lorenzo +10 more
TL;DR: In this article, a bionanocomposite (BNC) composed of titanium dioxide nanoparticles (TiO2-NPs), photocatalytically reduced graphene, and lactate oxidase was developed for the determination of lactate.
Amperometric L-lactate sensor based on sol-gel processing of an enzyme-linked silicon alkoxide.
TL;DR: A novel organically modified silica material has been prepared by covalent linking of the carboxylic acid group of lactate dehydrogenase to the amino group of an organoalkoxysilane precursor via a carbodiimide coupling reaction during the sol-gel process to fabricate a leak-free biosensor.
40
Related Papers (5)
Wei Gao,Wei Gao,Sam Emaminejad,Sam Emaminejad,Sam Emaminejad,Hnin Yin Yin Nyein,Hnin Yin Yin Nyein,Samyuktha Challa,Kevin Chen,Kevin Chen,Austin J Peck,Hossain M. Fahad,Hossain M. Fahad,Hiroki Ota,Hiroki Ota,Hiroshi Shiraki,Hiroshi Shiraki,Daisuke Kiriya,Daisuke Kiriya,Der Hsien Lien,George A. Brooks,Ronald W. Davis,Ali Javey,Ali Javey +23 more