Biosensors based on electrochemical lactate detection: A comprehensive review
TL;DR: A comparative study to summarize the L-lactate biosensors on the basis of different analytical properties in terms of fabrication, sensitivity, detection limit, linearity, response time and storage stability has been done.
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Abstract: Lactate detection plays a significant role in healthcare, food industries and is specially necessitated in conditions like hemorrhage, respiratory failure, hepatic disease, sepsis and tissue hypoxia. Conventional methods for lactate determination are not accurate and fast so this accelerated the need of sensitive biosensors for high-throughput screening of lactate in different samples. This review focuses on applications and developments of various electrochemical biosensors based on lactate detection as lactate being essential metabolite in anaerobic metabolic pathway. A comparative study to summarize the L-lactate biosensors on the basis of different analytical properties in terms of fabrication, sensitivity, detection limit, linearity, response time and storage stability has been done. It also addresses the merits and demerits of current enzyme based lactate biosensors. Lactate biosensors are of two main types - lactate oxidase (LOD) and lactate dehydrogenase (LDH) based. Different supports tried for manufacturing lactate biosensors include membranes, polymeric matrices-conducting or non-conducting, transparent gel matrix, hydrogel supports, screen printed electrodes and nanoparticles. All the examples in these support categories have been aptly discussed. Finally this review encompasses the conclusion and future emerging prospects of lactate sensors.
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Citations
Fabrication and Characterization of Carbon Nanotube-modified Carbon Paper-based Lactate Oxidase-catalase Electrode
Ke Shi,Varshini Selvarajan,Yeong-Yil Yang,Hyug-Han Kim,Chang-Joon Kim +4 more
TL;DR: Researchers developed a lactate electrode by modifying carbon paper with single-walled carbon nanotubes and immobilizing lactate oxidase and catalase, achieving a 1.7-fold increase in current and a linear response up to 20 mM lactate concentration.
Improving the performance of lactate/oxygen biofuel cells using a microfluidic design
R.A. Escalona-Villalpando,Russell C. Reid,Ross D. Milton,Luis Gerardo Arriaga,Shelley D. Minteer,Janet Ledesma-García +5 more
TL;DR: In this paper, a microfluidic lactate/oxygen enzymatic biofuel cell with a ferrocene-based redox polymer (dimethylferrocene modified linear polyethylenimine, FcMe2-LPEI) was used to facilitate direct electron transfer at the biocathode.
Rapid Measurement of Lactate in the Exhaled Breath Condensate: Biosensor Optimization and In-Human Proof of Concept
Shulin Zhang,Yu Chih Chen,Alaa Riezk,Damien Ming,Lidiia Tsvik,Leander Sützl,Alison Holmes,Danny O'Hare +7 more
TL;DR: In this article , an amperometric biosensor was developed and its application in EBC lactate detection was investigated in a human at rest and after 30 min of intense aerobic cycling exercise, which showed good agreement with fluorometric and triple quadrupole liquid chromatography mass spectrometry reference methods.
Innovative Multipolymer-Based Electrochemical Biosensor Built on a Sonogel–Carbon Electrode Aiming for Continuous and Real-Time Lactate Determination in Physiological Samples: A New Scenario to Exploit Additive Printing
Alfonso Sierra-Padilla,Juan José García‐Guzmán,Lorena Blanco-Díaz,Dolores Bellido-Milla,José María Palacios‐Santander,Laura Cubillana Aguilera +5 more
- 26 Sep 2023
TL;DR: A novel amperometric biosensor for lactate determination based on a sonogel–carbon electrode and a multipolymer-coated lactate oxidase enzyme is developed and evaluated. The biosensor exhibits high sensitivity, wide linear working range, and selectivity. A microfluidic cell is designed and fabricated to enable continuous lactate determination.
Osmotically Enabled Wearable Patch for Sweat Harvesting and Lactate Quantification.
Tamoghna Saha,Jennifer Fang,Sneha Mukherjee,Charles T. Knisely,Michael D. Dickey,Orlin D. Velev +5 more
TL;DR: Researchers developed a wearable patch that harnesses sweat via osmosis and capillary action, enabling lactate quantification in sweat and correlating with blood levels during high-intensity exercise, offering a potential tool for muscle health monitoring.
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