Journal Article10.23736/S1825-859X.19.00004-5
Biopsia liquida: una review
Fabio Del Ben,Michela Bulfoni,Matteo Turetta,Giulia Brisotto,Agostino Steffan,Francesco Curcio +5 more
- 01 May 2019
- Vol. 15, Iss: 1
About: The article was published on 01 May 2019.
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References
Concomitant ALK translocation and EGFR mutation in lung cancer: a comparison of direct sequencing and sensitive assays and the impact on responsiveness to tyrosine kinase inhibitor
Jae Kyung Won,Bhumsuk Keam,Jiwon Koh,Hyeseong Cho,Yoon Kyung Jeon,Tae Min Kim,Su-Nam Lee,Dong Soo Lee,Dong Wan Kim,Doo Hyun Chung +9 more
TL;DR: A portion of NSCLC patients have concomitant EGFR and ALK alterations and the frequency of co-alteration detection increases when sensitive detection methods for EGFR mutation are applied.
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Protein acetylation and histone deacetylase expression associated with malignant breast cancer progression.
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TL;DR: Overall, there was a global pattern of hypoacetylation associated with progression from normal to DCIS to IDC, and the findings suggest that the reversal of this hypo acetylation in DCIS and IDC could be an early measure of HDAC inhibitor activity.
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In patients with metastatic breast cancer the identification of circulating tumor cells in epithelial-to-mesenchymal transition is associated with a poor prognosis
Michela Bulfoni,Lorenzo Gerratana,Fabio Del Ben,Stefania Marzinotto,Marisa Sorrentino,Matteo Turetta,Giacinto Scoles,Barbara Toffoletto,Miriam Isola,Carlo Alberto Beltrami,Carla Di Loreto,Antonio Paolo Beltrami,Fabio Puglisi,Daniela Cesselli +13 more
TL;DR: The fraction of CD45neg cells co-expressing epithelial and mesenchymal markers (EM CTC) was significantly associated with poorer PFS and OS, computed, this latter, both from the diagnosis of a stage IV disease and from the initial CTC assessment.
EGFR mutation status in tumour-derived DNA from pleural effusion fluid is a practical basis for predicting the response to gefitinib
Hiroshi Kimura,Yutaka Fujiwara,Takashi Sone,Hideo Kunitoh,Tomohide Tamura,Kazuo Kasahara,Kazuto Nishio +6 more
TL;DR: The results suggest that DNA in pleural effusion fluid can be used to detect EGFR mutations and that the EGFR mutation status may be useful as a predictor of the response to gefitinib.
Comparison of estrogen and progesterone receptor status of circulating tumor cells and the primary tumor in metastatic breast cancer patients.
Bahriye Aktas,Volkmar Müller,Mitra Tewes,J Zeitz,Sabine Kasimir-Bauer,Christian R. Loehberg,Brigitte Rack,Andreas Schneeweiss,Tanja Fehm +8 more
TL;DR: This study evaluated blood samples of 193 metastatic breast cancer patients participating in the German DETECT study to reevaluate the ER/PR expression by CTCs and to compare the hormone receptor status expression profile of C TCs with the primary tumor.
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