Journal Article10.23736/S1825-859X.19.00004-5
Biopsia liquida: una review
Fabio Del Ben,Michela Bulfoni,Matteo Turetta,Giulia Brisotto,Agostino Steffan,Francesco Curcio +5 more
- 01 May 2019
- Vol. 15, Iss: 1
About: The article was published on 01 May 2019.
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Mutational Analysis of Circulating Tumor Cells Using a Novel Microfluidic Collection
Wael A. Harb,Andrea Fan,Tony Tran,Daniel C. Danila,David N. Keys,Michael P. Schwartz,Cristian Ionescu-Zanetti +6 more
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TL;DR: A microfluidic platform (IsoFlux) is presented that uses flow control and immunomagnetic capture to enhance CTC isolation and an assay for detecting KRAS mutations was described along with data from patients with colorectal cancer.
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Patient-Paired Sample Congruence Between 2 Commercial Liquid Biopsy Tests.
Gonzalo Torga,Kenneth J. Pienta +1 more
TL;DR: This cohort study examines the reliability and potential utility of 2 commercially available liquid biopsy assays for reported mutations in cell-free DNA.
Isolation and mutational analysis of circulating tumor cells from lung cancer patients with magnetic sifters and biochips
Christopher M. Earhart,Casey E. Hughes,Richard S. Gaster,Chin Chun Ooi,Robert J. Wilson,Lisa Y. Zhou,Eric W. Humke,Lingyun Xu,Dawson J. Wong,Stephen B. Willingham,Erich J. Schwartz,Irving L. Weissman,Irving L. Weissman,Stefanie S. Jeffrey,Joel W. Neal,Rajat Rohatgi,Heather A. Wakelee,Shan X. Wang,Shan X. Wang +18 more
TL;DR: A continuing development of a magnetic separation device, the magnetic sifter, which is a miniature microfluidic chip with a dense array of magnetic pores that offers high efficiency capture of tumor cells, labeled with magnetic nanoparticles, from whole blood with high throughput and efficient release of captured cells.
Noninvasive Detection of Activating Estrogen Receptor 1 (ESR1) Mutations in Estrogen Receptor–Positive Metastatic Breast Cancer
David S. Guttery,Karen Page,Allison Hills,Laura Woodley,Stephanie D. Marchese,Basma Rghebi,Robert K. Hastings,Jin-Li Luo,J. Howard Pringle,Justin Stebbing,R. Charles Coombes,Simak Ali,Jacqueline A Shaw +12 more
TL;DR: Early identification of ESR1 mutations by liquid biopsy might allow for cessation of ineffective endocrine therapies and switching to other treatments, without the need for tissue biopsy and before the emergence of metastatic disease.
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DNA Methylation of Tumor Suppressor and Metastasis Suppressor Genes in Circulating Tumor Cells
Maria Chimonidou,Areti Strati,Alexandra Tzitzira,Georgia Sotiropoulou,N. Malamos,Vasilis Georgoulias,Evi Lianidou +6 more
TL;DR: DNA methylation of tumor suppressor and metastasis suppressor genes is a hallmark of CTCs and confirms their heterogeneity, which may underlie the acquisition of malignant properties, including their stem-like phenotype.