Biomarkers of aging
Hà Dương Xuân Bảo,Jiani Cao,Mengting Chen,Min Chen,Wei Chen,Xiao Chen,Yanhao Chen,Yu Chen,Yutian Chen,Zhiyang Chen,Jagadish K. Chhetri,Yingjie Ding,Junlin Feng,Jun Guo,Mengmeng Guo,Chuting He,Yujuan Jia,Haiping Jiang,Ying Jing,Dingfeng Li,Jiaming Li,Jingyi Li,Qinhao Liang,Rui Liang,Xiaoqian Liu,Zuojun Liu,Oscar Junhong Luo,Jianwei Lv,Jingyi Ma,Jiawei Nie,Xinhua Qiao,Xinpei Sun,Xiaoqiang Tang,Jianfang Wang,Qiaoran Wang,Siyuan Wang,Xuan Wang,Yaning Wang,Yuhan Wang,Kai Xia,Fuhui Liao,Lingyan Xu,Yingying Xu,Haoteng Yan,Liang Yang,Ruici Yang,Yuanxin Yang,Yilin Ying,Le Zhang,Weiwei Zhang,Wenwan Zhang,Xuning Zhang,Zhuo Zhang,Min Zhou,Rui Zhou,Qingchen Zhu,Zhengmao Zhu,Feng Cao,Zhongwei Cao,P. Chang,Chang Chen,Guobing Chen,Hou-Zao Chen,Jun Chen,Weimin Ci,Bi-Sen Ding,Qiurong Ding,Feng Gao,J.H. Han,Kai Huang,Zhenyu Ju,Qing-Peng Kong,Ji Li,Jian Li,Xin Li,Baohua Liu,Feng Liu,Lin Liu,Qiang Liu,Qiang Liu,Xingguo Liu,Yong Liu,Xianghang Luo,Shuai Ma,Xinran Ma,Zhiyong Mao,Jing Nie,Yaojin Peng,Jing Qu,Jie Ren,Ruibao Ren,Moshi Song,Zhou Songyang,Yi E. Sun,Mei Tian,Sheng Wang,Si Qi Wang,Xia Wang,Xiaoning Wang,Yan-Jiang Wang,Yunfang Wang,Catherine C L Wong,Andy Peng Xiang,Yichuan Xiao,Zhengwei Xie,Daichao Xu,Jing Ye,Rui Yue,Cuntai Zhang,Hongbo Zhang,Liang Zhang,Weiqi Zhang,Yong Zhang,Yun-wu Zhang,Zhuohua Zhang,Tongbiao Zhao,Yuzheng Zhao,Dahai Zhu,Weiguo Zou,Gang Pei,Guang-Hui Liu +120 more
TL;DR: Aging biomarkers are a combination of biological parameters to assess agerelated changes, track the physiological aging process, and predict the transition into a pathological status as discussed by the authors , which can help us answer the following three fundamental questions in aging research: How old are we? Why do we get old? And how can we age slower?
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Abstract: Aging biomarkers are a combination of biological parameters to (i) assess age-related changes, (ii) track the physiological aging process, and (iii) predict the transition into a pathological status. Although a broad spectrum of aging biomarkers has been developed, their potential uses and limitations remain poorly characterized. An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research: How old are we? Why do we get old? And how can we age slower? This review aims to address this need. Here, we summarize our current knowledge of biomarkers developed for cellular, organ, and organismal levels of aging, comprising six pillars: physiological characteristics, medical imaging, histological features, cellular alterations, molecular changes, and secretory factors. To fulfill all these requisites, we propose that aging biomarkers should qualify for being specific, systemic, and clinically relevant.
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References
Inflammaging: disturbed interplay between autophagy and inflammasomes
Antero Salminen,Kai Kaarniranta,Anu Kauppinen +2 more
- 07 Mar 2012
TL;DR: In conclusion, inhibition of autophagic capacity with aging generates the inflammaging condition via the activation of inflammasomes, in particular NLRP3, which provoke inflammatory responses and accelerate the aging process by inhibiting autophagy.
Circadian clock control of endocrine factors
TL;DR: Observations suggest that strategies designed to realign normal circadian rhythmicities hold potential for the treatment of various endocrine-related disorders.
470
Proliferation-Dependent Alterations of the DNA Methylation Landscape Underlie Hematopoietic Stem Cell Aging
Isabel Beerman,Christoph Bock,Christoph Bock,Brian S. Garrison,Brian S. Garrison,Zachary D. Smith,Zachary D. Smith,Hongcang Gu,Alexander Meissner,Alexander Meissner,Derrick J. Rossi +10 more
TL;DR: It is found that age-associated HSC decline, replicative limits, and DNA methylation are largely dependent on the proliferative history of HSCs, yet appear to be telomere-length independent.
470
Clonal analysis reveals multiple functional defects of aged murine hematopoietic stem cells
TL;DR: As shown using clonal assays, the mouse HSC population undergoes quantitative as well as qualitative changes with age, including lineage differentiation, HSC pool size, marrow-homing efficiency, and self-renewal.
The Association Between Age and Nephrosclerosis on Renal Biopsy Among Healthy Adults
Andrew D. Rule,Hatem Amer,Lynn D. Cornell,Sandra J. Taler,Fernando G. Cosio,Walter K. Kremers,Stephen C. Textor,Mark D. Stegall +7 more
TL;DR: Kidney function and chronic kidney disease risk factors do not explain the strong association between age and nephrosclerosis in healthy adults, and adjustment for kidney function and risk factor covariates failed to explain the age-related increase in the prevalence of nephosclerosis.
467
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