Bioelectrical impedance modelling of gentamicin pharmacokinetic parameters.
TL;DR: Bioelectrical impedance analysis was used to develop descriptive models of gentamicin pharmacokinetic parameters in 30 adult in-patients receiving therapy with gentamicine and multiple regression equations were developed for clearance, elimination rate constant and volume of distribution at steady state.
read more
Abstract: 1. Bioelectrical impedance analysis was used to develop descriptive models of gentamicin pharmacokinetic parameters in 30 adult in-patients receiving therapy with gentamicin. 2. Serial blood samples obtained from each subject at steady state were analyzed and used to derive gentamicin pharmacokinetic parameters. 3. Multiple regression equations were developed for clearance, elimination rate constant and volume of distribution at steady state and were all statistically significant at P less than 0.05. 4. Clinical validation of this innovative technique is warranted before clinical use is recommended.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
Prediction of aminoglycoside distribution space in neonates by multiple frequency bioelectrical impedance analysis
Barbara E. Lingwood,J. P. Coghlan,L. C. Ward,B. G. Charles,Paul B. Colditz +4 more
TL;DR: A bioelectrical impedance-based prediction equation for prediction of gentamicin distribution space in neonates was produced, which represents only a small improvement over that using weight alone, but is of clinical significance due to the narrow margin between therapeutic and toxic levels for Gentamicin.
References
Prediction of Creatinine Clearance from Serum Creatinine
Donald W. Cockcroft,M H Gault +1 more
TL;DR: A formula has been developed to predict Creatinine clearance from serum creatinine (Scr) in adult males: Ccr = (140 – age) (wt kg)/72 × Scr (mg/100ml) (15% less i).
15.8K
•Book
Classical and modern regression with applications
Raymond H. Myers
- 01 Jan 1986
TL;DR: In this article, the authors focus on concepts with a blend between illustrations using real data sets and mathematical and conceptual development and emphasize applications with examples that illustrate nearly all the techniques discussed, including simultaneous influence, maximum likelihood estimation of parameters, and the plotting of residuals.
4.6K
Assessment of fat-free mass using bioelectrical impedance measurements of the human body
TL;DR: Data indicate that the bioelectrical impedance technique is a reliable and valid approach for the estimation of human body composition and further validation of this method is recommended in subjects with abnormal body composition.
1.8K
Some suggestions for measuring predictive performance
Lewis B. Sheiner,Stuart L. Beal +1 more
TL;DR: The performance of a prediction or measurement method is often evaluated by computing the correlation coefficient and/or the regression of predictions on true (reference) values, but these provide only a poor description of predictive performance.
1.6K