Biodistribution of 68/67Ga-Radiolabeled Sphingolipid Nanoemulsions by PET and SPECT Imaging.
Sandra Díez-Villares,Sandra Díez-Villares,Juan Pellico,Noemí Gómez-Lado,Santiago Grijalvo,Sandra Alijas,Ramon Eritja,Fernando Herranz,Pablo Aguiar,Maria de la Fuente +9 more
TL;DR: Authors in this article also acknowledge the financial support from Axencia Galega de Innovacion (GAIN) and Xunta de Galicia (IN848C_20170721_7) and ISCII (FI19/00206).
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Abstract: Authors thank the financial support given by Instituto de Salud Carlos III (ISCIII) and European Regional Development Fund (FEDER) (PI15/00828, PI18/00176 and DTS18/00133), by ERA-NET EURONANOMED III project METASTARG (AC18/00045) and by Asociacion Espanola Contra el Cancer (AECC, IDEAS18153DELA). The first author also acknowledges the financial support from Axencia Galega de Innovacion (GAIN) and Xunta de Galicia (IN848C_20170721_7) and ISCII (FI19/00206).
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Sphingomyelin nanosystems decorated with TSP-1 derived peptide targeting senescent cells.
Raneem Jatal,Sofia Mendes Saraiva,Carlos Vázquez-Vázquez,Eric Lelièvre,Olivier Coqueret,Rafael López-López,María Candelaria de la Fuente +6 more
TL;DR: In this article , a 10 amino acid peptide derived from TSP1 protein is used to target the CD47 receptor present in the surface of senescent cells and demonstrate senolytic activity.
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Before in vivo studies: In vitro screening of sphingomyelin nanosystems using a relevant 3D multicellular pancreatic tumor spheroid model.
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TL;DR: A 3D heterotype spheroid model of pancreatic tumor has been constructed to investigate the potential of bare and polyethylene glycol-modified lipid nanosystems in terms of their ability to penetrate the tumor mass and deliver drugs as discussed by the authors .
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Modulation of Colorectal Tumor Behavior via lncRNA TP53TG1-Lipidic Nanosystem
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Quantitative PET tracking of intra-articularly administered 89Zr-peptide-decorated nanoemulsions.
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TL;DR: In this paper , the authors compared the biodistribution and retention time of a senolytic peptide (PEP), with potential application in osteoarthritis disease, and this peptide encapsulated in a drug delivery system (DDS) based on a lipid nanoemulsion by using positron emission tomography (PET) imaging.
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PEGylation Effects on the Interaction of Sphingomyelin Nanoemulsions with Serum Albumin: A Thermodynamic Investigation
Daniela Gheorghe,Sandra Díez-Villares,Romica Sandu,Ana Neacsu,Adriana Petruta Serban,Alina Botea-Petcu,Vlad Tudor Popa,Jenifer Garcia-Fernandez,María de la Fuente Freire,Florina Teodorescu,Speranta Tanasescu +10 more
TL;DR: In this article , the binding parameters (binding constant, binding stoichiometry, enthalpy, Gibbs energy, and entropy changes of binding) are evaluated by the isothermal titration calorimetry with a MicroCaliTC200 equipment.
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