Journal Article10.1002/PI.2108
Biodegradable polymers applied in tissue engineering research: a review
451
TL;DR: This paper aims to review the latest developments from a scaffold material perspective, mainly pertaining to new generations of scaffolds based on synthetic and natural polymers aimed at mimicking the structural characteristics of natural extracellular matrix.
read more
Abstract: Typical applications and research areas of polymeric biomaterials include tissue replacement, tissue augmentation, tissue support, and drug delivery. In many cases the body needs only the temporary presence of a device/biomaterial, in which instance biodegradable and certain partially biodegradable polymeric materials are better alternatives than biostable ones. Recent treatment concepts based on scaffold-based tissue engineering principles differ from standard tissue replacement and drug therapies as the engineered tissue aims not only to repair but also regenerate the target tissue. Cells have been cultured outside the body for many years; however, it has only recently become possible for scientists and engineers to grow complex three-dimensional tissue grafts to meet clinical needs. New generations of scaffolds based on synthetic and natural polymers are being developed and evaluated at a rapid pace, aimed at mimicking the structural characteristics of natural extracellular matrix. This review focuses on scaffolds made of more recently developed synthetic polymers for tissue engineering applications. Currently, the design and fabrication of biodegradable synthetic scaffolds is driven by four material categories: (i) common clinically established polymers, including polyglycolide, polylactides, polycaprolactone; (ii) novel di- and tri-block polymers; (iii) newly synthesized or studied polymeric biomaterials, such as polyorthoester, polyanhydrides, polyhydroxyalkanoate, polypyrroles, poly(ether ester amide)s, elastic shape-memory polymers; and (iv) biomimetic materials, supramolecular polymers formed by self-assembly, and matrices presenting distinctive or a variety of biochemical cues. This paper aims to review the latest developments from a scaffold material perspective, mainly pertaining to categories (ii) and (iii) listed above. Copyright © 2006 Society of Chemical Industry
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
25th Anniversary Article: Rational Design and Applications of Hydrogels in Regenerative Medicine
Nasim Annabi,Nasim Annabi,Ali Tamayol,Ali Tamayol,Jorge Alfredo Uquillas,Jorge Alfredo Uquillas,Mohsen Akbari,Mohsen Akbari,Luiz E. Bertassoni,Luiz E. Bertassoni,Chaenyung Cha,Chaenyung Cha,Gulden Camci-Unal,Gulden Camci-Unal,Mehmet R. Dokmeci,Mehmet R. Dokmeci,Nicholas A. Peppas,Ali Khademhosseini,Ali Khademhosseini +18 more
TL;DR: The development of advanced hydrogel with tunable physiochemical properties is highlighted, with particular emphasis on elastomeric, light‐sensitive, composite, and shape‐memory hydrogels, and a number of potential applications and challenges in the utilization in regenerative medicine are reviewed.
Three-dimensional cell culture matrices: state of the art.
TL;DR: This review presents the status of state-of-the-art 3D cell-growth techniques and scaffolds and analyze them from the perspective of materials properties, manufacturing, and functionality and outlines key challenges in this field.
1.1K
Poly-є-caprolactone based formulations for drug delivery and tissue engineering: A review
TL;DR: This review aims to provide an up to date of drugs incorporated in different PCL based formulations, their purpose and brief outcomes.
910
Biodegradable Polymers- A Review on Recent Trends and Emerging Perspectives
TL;DR: A review of the state-of-the-art on biodegradable polymers can be found in this paper, where the salient features of the design and properties of these polymers are discussed.
720
Scaffold: A Novel Carrier for Cell and Drug Delivery
TL;DR: The present review gives a detailed account of the need for the development of scaffolds along with the materials used and techniques adopted to manufacture scaffolds for tissue engineering and for prolonged drug delivery.
544
References
Biodegradable, Elastic Shape Memory Polymers for Potential Biomedical Applications
Andreas Lendlein,Robert Langer +1 more
TL;DR: A group of degradable thermoplastic polymers that are able to change their shape after an increase in temperature enables bulky implants to be placed in the body through small incisions or to perform complex mechanical deformations automatically.
2.3K
Light-induced shape-memory polymers
TL;DR: Polymers containing cinnamic groups can be deformed and fixed into pre-determined shapes—such as elongated films and tubes, arches or spirals—by ultraviolet light illumination and can recover their original shape at ambient temperatures when exposed to ultraviolet light of a different wavelength.
2K
Chitosan: a versatile biopolymer for orthopaedic tissue-engineering.
TL;DR: The ability to manipulate and reconstitute tissue structure and function using chitosan has tremendous clinical implications and is likely to play a key role in cell and gene therapies in coming years.
1.6K
Polymeric scaffolds for bone tissue engineering.
Xiaohua Liu,Peter X. Ma +1 more
TL;DR: Various architectural parameters of scaffolds important for bone tissue engineering (e.g. porosity, pore size, interconnectivity, and pore-wall microstructures) are discussed and surface modification of scaffolding is also discussed based on the significant effect of surface chemistry on cells adhesion and function.
1.3K
A tough biodegradable elastomer
TL;DR: A tough biodegradable elastomer is designed, synthesized, and characterized from biocompatible monomers that forms a covalently crosslinked, three-dimensional network of random coils with hydroxyl groups attached to its backbone.
1.3K