Open AccessBook
Biochemistry of Copper
Maria C. Linder
- 31 Oct 1991
650
TL;DR: This chapter discusses Copper in Nonvertebrate Organisms, its role in Growth and Development, and the role of Copper in Disease.
read more
Abstract: 1. Introduction and Overview of Copper as an Element Essential for Life.- 2. Absorption of Copper from the Digestive Tract.- 3. Copper Uptake by Nongastrointestinal Vertebrate Cells.- 4. Extracellular Copper Substituents and Mammalian Copper Transport.- 5. Excretion of Copper in the Mammal.- 6. Copper within Vertebrate Cells.- 7. Copper and Metabolic Regulation.- 8. Copper in Growth and Development.- 9. Copper and Disease.- 10. Copper in Nonvertebrate Organisms.- Appendix A: Copper Contents of Foods.- Appendix B: Copper Content of Human and Animal Tissues.- References.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
Molecular imaging of cancer with copper-64 radiopharmaceuticals and positron emission tomography (PET).
TL;DR: Specific examples of PET imaging with new and improved (64)Cu-based radiopharmaceuticals are discussed, highlighting the study of some of the key cancer biomarkers, such as epidermal growth-factor receptor (EGFR), somatostatin receptors (SSRs), and integrin alpha(v)beta(3).
302
Copper chelation chemistry and its role in copper radiopharmaceuticals.
TL;DR: The necessary characteristics of an effective ( 64)Cu chelator are discussed, while highlighting the development and evaluation of (64)Cu-complexes attached to biologically-targeted ligands.
Ctr1 drives intestinal copper absorption and is essential for growth, iron metabolism, and neonatal cardiac function
TL;DR: The generation of intestinal epithelial cell-specific Ctr1 knockout mice are described and identified as the major factor driving intestinal Cu absorption in mammals, indicative of a critical neonatal metabolic requirement for Cu that is provided by intestinal Ctr 1.
295
Cellular Copper Transport
Chris D. Vulpe,Seymour Packman +1 more
TL;DR: Observations suggest that yeast and bacterial copper transport proteins, or individual domains of these proteins, may generally have homologues in mammalian systems.
287
Regulation of brain iron and copper homeostasis by brain barrier systems: implication in neurodegenerative diseases.
Wei Zheng,Andrew D. Monnot +1 more
TL;DR: The mechanism by which pertinent metal transporters in the barriers, such as the transferrin receptor (TfR), divalent metal transporter (DMT1), copper transporter (CTR1), ATP7A/B, and ferroportin (FPN), regulate metal movement across the barriers is explored.
282