Biochemical Marker Reference Values across Pediatric, Adult, and Geriatric Ages: Establishment of Robust Pediatric and Adult Reference Intervals on the Basis of the Canadian Health Measures Survey
Khosrow Adeli,Victoria Higgins,Michelle Nieuwesteeg,Joshua E. Raizman,Yunqi Chen,Suzy L Wong,David Blais,David Blais +7 more
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TL;DR: Understanding the fluctuations in biochemical markers over a wide age range provides important insight into biological processes and facilitates clinical application of biochemical markers to monitor manifestation of various disease states.
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Abstract: BACKGROUND: Biological covariates such as age and sex can markedly influence biochemical marker reference values, but no comprehensive study has examined such changes across pediatric, adult, and geriatric ages. The Canadian Health Measures Survey (CHMS) collected comprehensive nationwide health information and blood samples from children and adults in the household population and, in collaboration with the Canadian Laboratory Initiative on Pediatric Reference Intervals (CALIPER), examined biological changes in biochemical markers from pediatric to geriatric age, establishing a comprehensive reference interval database for routine disease biomarkers. METHODS: The CHMS collected health information, physical measurements, and biosamples (blood and urine) from approximately 12 000 Canadians aged 3–79 years and measured 24 biochemical markers with the Ortho Vitros 5600 FS analyzer or a manual microplate. By use of CLSI C28-A3 guidelines, we determined age- and sex-specific reference intervals, including corresponding 90% CIs, on the basis of specific exclusion criteria. RESULTS: Biochemical marker reference values exhibited dynamic changes from pediatric to geriatric age. Most biochemical markers required some combination of age and/or sex partitioning. Two or more age partitions were required for all analytes except bicarbonate, which remained constant throughout life. Additional sex partitioning was required for most biomarkers, except bicarbonate, total cholesterol, total protein, urine iodine, and potassium. CONCLUSIONS: Understanding the fluctuations in biochemical markers over a wide age range provides important insight into biological processes and facilitates clinical application of biochemical markers to monitor manifestation of various disease states. The CHMS-CALIPER collaboration addresses this important evidence gap and allows the establishment of robust pediatric and adult reference intervals.
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The Canadian laboratory initiative on pediatric reference intervals: A CALIPER white paper.
TL;DR: The Canadian Laboratory Initiative on Pediatric Reference Intervals (CALIPER) as discussed by the authors has made significant strides towards improving pediatric healthcare in Canada and globally by collecting health information and blood samples from over 9700 community children and adolescents, and has established a comprehensive database of age and sex-specific reference intervals for over 100 biomarkers of pediatric disease.
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Complex Biological Profile of Hematologic Markers Across Pediatric, Adult, and Geriatric Ages: Establishment of Robust Pediatric and Adult Reference Intervals on the Basis of the Canadian Health Measures Survey
Khosrow Adeli,Joshua E. Raizman,Yunqi Chen,Victoria Higgins,Michelle Nieuwesteeg,Mohamed Abdelhaleem,Suzy L Wong,David Blais,David Blais +8 more
TL;DR: The robust dataset generated in this study has allowed observation of dynamic biological profiles of several hematology markers and the establishment of comprehensive age- and sex-specific reference intervals that may contribute to accurate monitoring of pediatric, adult, and geriatric patients.
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Pediatric Reference Intervals
Steven J. Soldin,Jocelyn M. Hicks,Kurt C Gunter,Alain Colaço +3 more
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137
Blood eosinophil count in the general population: typical values and potential confounders
Sylvia Hartl,Marie-Kathrin Breyer,Otto C. Burghuber,Alina Ofenheimer,Andrea Schrott,Matthias Urban,Alvar Agusti,Michael Studnicka,Emiel F.M. Wouters,Robab Breyer-Kohansal +9 more
TL;DR: The level of circulating blood eosinophils in healthy subjects is much lower than currently considered, is age dependent until 18 years, is higher in males and is influenced by several multimorbid conditions and lifestyle factors.
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Trained immunity as a molecular mechanism for BCG immunotherapy in bladder cancer.
Jelmer H. van Puffelen,Samuel T. Keating,Egbert Oosterwijk,Antoine G. van der Heijden,Mihai G. Netea,Mihai G. Netea,Leo A. B. Joosten,Leo A. B. Joosten,Sita H. Vermeulen +8 more
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References
Reference intervals of common serum analytes of Hong Kong Chinese
TL;DR: Reference intervals of common serum analytes have been set up for the local Chinese population as mentioned in this paper to provide clinicians with reliable reference intervals that they can confidently rely on for the diagnosis and management of patients.
31
Pediatric reference intervals determined in ambulatory and hospitalized children and juveniles.
TL;DR: The results confirm in most cases the typical age concentration relationship of the measured quantities documented for similar methods but in some critical cases, in particular for sTfR and ferritin, the study produces limits which differ distinctly from those earlier reported.
29
Reference Intervals of Serum Sodium, Potassium, and Chlorine in Chinese Han Population and Comparison of Two ISE Methods.
Keke Jia,Chuanbao Zhang,Xianzhang Huang,Lanlan Wang,Xiaoke Hao,Runqing Mu,Baishen Pan,Jie Zhang,Wenxiang Chen,Ning Xu,Guixing Li,Yueyun Ma,Ming Ma,Wei Guo,Hong Shang +14 more
TL;DR: Two kinds of ion‐selective electrode (ISE) methods were commonly used to determine K, Na, and Cl levels in China, the difference between these two methods needs to be evaluated.
Normative role for medical humanities
TL;DR: In this paper, the project to rigorously expose the theoretical foundations of medical humanities to jurisprudential, philosophic and regulation-theory analysis could see it emerge as an important strategy for awakening and supporting that sense of conscience which the foundational ethical codes and the central instruments of human rights, place at the heart not only of rule obedience, but norm development.
6
Novel Modeling of Reference Values of Cardiovascular Risk Factors in Children Aged 7 to 20 Years
H. Mellerio,Corinne Alberti,Céline Druet,Florence Capelier,Isabelle Mercat,Emilie Josserand,Sylviane Vol,Jean Tichet,Claire Levy-Marchal +8 more
TL;DR: These ranges for waist circumference, systolic and diastolic blood pressures, fasting lipid levels, total cholesterol, high-density lipoprotein cholesterol, low-density cholesterol, triglycerides, glucose, and insulin can be used as references for European children to monitor cardiovascular risk factors and to plan interventions and education programs.