Journal Article10.1080/14712598.2022.2088277
Bio-nano scale modifications of melittin for improving therapeutic efficacy
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TL;DR: Melittin-nanoconjugation may be one of the best-optimized strategies for improving peptide delivery, increasing its therapeutic efficacy, and providing minimal nonspecific cellular lytic activity.
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Abstract: ABSTRACT Introduction Melittin (MLT), a natural membrane-active component, is the most prominent cytolytic peptide from bee venom. Remarkable biological properties of MLT, including anti-inflammatory, antimicrobial, anticancer, anti-protozoan, and antiarthritic activities, make it an up-and-coming therapeutic candidate for a wide variety of human diseases. Therapeutic applications of MLT may be hindered due to low stability, high toxicity, and weak tissue penetration. Different bio-nano scale modifications hold promise for improving its functionality and therapeutic efficacy. Areas covered In the current review, we aimed to provide a comprehensive insight into strategies used for MLT conjugations and modifications, cellular delivery of modified forms, and their clinical perspectives by reviewing the published literature on PubMed, Scopus, and Google Scholar databases. We also emphasized the MLT structure modifications, mechanism of action, and cellular toxicity. Expert opinion Developing new analogs and conjugates of MLT as a natural drug with improved functions and fewer side effects is crucial for the clinical translation of this approach worldwide, especially where the chemicals and synthetic drugs are more expensive or unavailable in the healthcare system. MLT-nanoconjugation may be one of the best-optimized strategies for improving peptide delivery, increasing its therapeutic efficacy, and providing minimal nonspecific cellular lytic activity.
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TL;DR: In this article , a hybrid peptide derived from Melittin and TAT was designed to inhibit CD147/Cyp A interaction in cancer types by blocking the CD147 and Cyp A interaction.
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References
Synthesis and Characterization of Stable Fluorocarbon Nanostructures as Drug Delivery Vehicles for Cytolytic Peptides
TL;DR: Melittin binds avidly to the nanoparticles and retains its pore-forming activity after contact-mediated delivery to model bilayer membrane (liposomes) thereby demonstrating the effectiveness of perfluorocarbon nanoparticles as unique nanocarriers for cytolytic peptides.
Pharmacological synergism of bee venom and melittin with antibiotics and plant secondary metabolites against multi-drug resistant microbial pathogens
TL;DR: Bee venom and melittin synergistically enhanced the bactericidal effect of several antimicrobial agents when applied in combination especially when the drugs affect several and differing molecular targets, which could lead to the development of novel or complementary antibacterial drugs against MDR pathogens.
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Honeybee venom and melittin suppress growth factor receptor activation in HER2-enriched and triple-negative breast cancer
Ciara Duffy,Anabel Sorolla,Anabel Sorolla,Edina Wang,Edina Wang,Emily Golden,Emily Golden,Eleanor A. Woodward,Eleanor A. Woodward,Kathleen Davern,Kathleen Davern,Diwei Ho,Elizabeth K. M. Johnstone,Elizabeth K. M. Johnstone,Elizabeth K. M. Johnstone,Kevin D. G. Pfleger,Andrew Redfern,K. Swaminathan Iyer,Boris Baer,Pilar Blancafort +19 more
- 01 Sep 2020
TL;DR: It is demonstrated that honeybee venom and its major component melittin potently induce cell death, particularly in the aggressive triple-negative and HER2-enriched breast cancer subtypes.
Conformation and Dynamics of Melittin Bound to Magnetically Oriented Lipid Bilayers by Solid-State 31P and 13C NMR Spectroscopy
TL;DR: Using (31)P NMR, it was found that melittin-lipid bilayers form magnetically oriented elongated vesicles with the long axis parallel to the magnetic field above the liquid crystalline-gel phase transition temperature (T(m) = 24 degrees C).
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The lowest conductance state of the alamethicin pore.
Wolfgang Hanke,Günther Boheim +1 more
TL;DR: High resolution experiments of the alamethicin pore demonstrate the existence of a further pore state at low conductance values, which seems to be impermeable to Ca2+, Cl, Tris-H+ and Hepes-, whereas the higher conductance states are not.
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