Bilirubin remodels murine white adipose tissue by reshaping mitochondrial activity and the coregulator profile of peroxisome proliferator-activated receptor α
Darren M. Gordon,Kari L. Neifer,Abdul-Rizaq Hamoud,Charles F. Hawk,Andrea L. Nestor-Kalinoski,Scott A. Miruzzi,Michael P. Morran,Samuel O. Adeosun,Jeffrey G. Sarver,Paul W. Erhardt,Robert E. McCullumsmith,David E. Stec,Terry D. Hinds +12 more
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TL;DR: It is concluded that bilirubin strongly affects organismal body weight by reshaping the PPARα coregulator profile, remodeling WAT to improve metabolic function, and reducing fat accumulation.
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About: This article is published in Journal of Biological Chemistry. The article was published on 17 Jul 2020. and is currently open access. The article focuses on the topics: Peroxisome proliferator-activated receptor & White adipose tissue.
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Citations
Bilirubin as a Metabolic Hormone: The Physiological Relevance of Low Levels
TL;DR: Call for a shift in the perspective of an old molecule that could benefit millions of patients with hypobilirubinemia, including targeting of pathways that regulate its production or turnover or the newly designed bilirubin nanoparticles.
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Molecular mechanisms of metabolic associated fatty liver disease (MAFLD): functional analysis of lipid metabolism pathways
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TL;DR: The metabolic-associated fatty liver disease (MAFLD) is a condition of fat accumulation in the liver in combination with metabolic dysfunction in the form of overweight or obesity and insulin resistance as discussed by the authors .
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Molecular mechanisms of metabolic associated fatty liver disease (MAFLD): functional analysis of lipid metabolism pathways
TL;DR: The details of the molecular mechanisms regulating hepatic lipids and the emerging therapies targeting these pathways as potential future treatments for MAFLD are discussed.
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The physiology of bilirubin: health and disease equilibrium.
TL;DR: In this paper , the beneficial effects of increasing plasma bilirubin levels to combat chronic diseases are discussed, and several key concepts to advance the field are provided, as well as emerging areas of interest.
63
Bilirubin Nanoparticles Reduce Diet-Induced Hepatic Steatosis, Improve Fat Utilization, and Increase Plasma β-Hydroxybutyrate.
Terry D. Hinds,Justin F. Creeden,Darren M. Gordon,Donald F. Stec,Matthew C. Donald,David E. Stec +5 more
TL;DR: The authors showed that bilirubin nanoparticles improved liver function and activated the hepatic β-oxidation pathway by increasing PPARα and acyl-coenzyme A oxidase 1.
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