Behavioral functions of the mesolimbic dopaminergic system: an affective neuroethological perspective.

TL;DR: A comprehensive comparative analysis of the two neural circuits of social behavior network and mesolimbic reward system concludes that they were already present in early vertebrates and proposes that these circuits form a larger social decision‐making (SDM) network that regulates adaptive behavior.

TL;DR: The results demonstrate that reward has an impact on vision that is independent of its role in the strategic establishment of endogenous attention and suggests that reward plays an important and undervalued role in attentional control.

TL;DR: Since all vertebrates appear to have some capacity for primal affective feelings, the implications for animal-welfare and how the authors ethically treat other animals are vast.

TL;DR: The structure of opponency is considered in terms of previous biases about the nature of the decision problems that animals face, the conflicts that may arise between Pavlovian and instrumental responses, and an additional spectrum joining invigoration to inhibition to shed light on aspects of the role of serotonin and its interactions with dopamine.

TL;DR: The principle of the “inverted U-shaped” function of D1 receptor activity mediating working memory does not necessarily apply to other PFC functions, and mesocortical DA modulation of distinct executive functions is subserved by dissociable profiles of DA receptor activity in the PFC.

TL;DR: The characteristics of clinical use (low doses administered orally and titrated for therapeutic effects) constrain methylphenidate's abuse.

TL;DR: Accumbens DA may be important for enabling rats to overcome behavioral constraints, such as work-related response costs, and may be critical for the behavioral organization and conditioning processes that enable animals to engage in vigorous responses, or to emit large numbers of responses in ratio schedules in the absence of primary reinforcement.

TL;DR: After dopaminergic depletion, cortical inputs and GABA interneurons might imbalance striatal projection neurons and represent two novel nondopaminergic mechanisms that might secondarily contribute to the pathophysiology of Parkinson's disease.