Open AccessJournal Article
Behavioral despair in mice: a primary screening test for antidepressants
Porsolt Rd,Bertin A,Jalfre M +2 more
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TL;DR: The mouse procedure is more rapid and less costly than that with rats and is thus more suitable for the primary screening of antidepressant drugs, suggesting that the procedure is selectively sensitive to antidepressant treatments.
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Abstract: A depressed state can be induced in mice by forcing them to swim in a narrow cylinder from which they cannot escape. After a brief period of vigorous activity the mice adopt a characteristic immobile posture which is readily identifiable. Immobility was reduced by tricyclic antidepressants, monoamine oxidase inhibitors and atypical antidepressants, as well as by electroconvulsive shock. Psychostimulants also reduced immobility but in contrast to antidepressants caused marked motor stimulation. Immobility was not affected by minor or major tranquilisers. These findings, closely parallel to those we have previously reported in rats, suggest that the procedure is selectively sensitive to antidepressant treatments. The mouse procedure is, however, more rapid and less costly than that with rats and is thus more suitable for the primary screening of antidepressant drugs.
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Citations
Contributions of animal models to the study of mood disorders
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Schisandra chinensis produces the antidepressant-like effects in repeated corticosterone-induced mice via the BDNF/TrkB/CREB signaling pathway.
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Abnormal response to stress and impaired NPS-induced hyperlocomotion, anxiolytic effect and corticosterone increase in mice lacking NPSR1.
Hongyan Zhu,Melissa K. Mingler,Melissa McBride,Andrew J. Murphy,David M. Valenzuela,George D. Yancopoulos,Michael T. Williams,Charles V. Vorhees,Marc E. Rothenberg +8 more
TL;DR: It is demonstrated that NPSR1 is essential in mediating NPS effects on behavior under basal conditions on locomotion, anxiety- and/or depression-like behavior, cortic testosterone levels, acoustic startle with prepulse inhibition, learning and memory, and under NPS-induced locomotor activation, anxiolysis, and corticosterone release.
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TL;DR: The data suggest that mouse behavior in the elevated plus-maze is not related tobehavior in the forced swimming test and that a Forced swimming test before the plus-Maze has an anxiogenic effect even after a one-week interval.
Melancholic-Like behaviors and circadian neurobiological abnormalities in melatonin MT1 receptor knockout mice.
Stefano Comai,Rafael Ochoa-Sanchez,Sergio Dominguez-Lopez,Francis Rodriguez Bambico,Gabriella Gobbi +4 more
TL;DR: These data demonstrate that melatonin MT1 receptor knockout mice recapitulate several behavioral and neurobiological circadian changes of human melancholic depression and suggest that theMT1 receptor may be implicated in the pathogenesis of melancholics depression and is a potential pharmacological target for this mental condition.