Open AccessJournal Article
Behavioral despair in mice: a primary screening test for antidepressants
Porsolt Rd,Bertin A,Jalfre M +2 more
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TL;DR: The mouse procedure is more rapid and less costly than that with rats and is thus more suitable for the primary screening of antidepressant drugs, suggesting that the procedure is selectively sensitive to antidepressant treatments.
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Abstract: A depressed state can be induced in mice by forcing them to swim in a narrow cylinder from which they cannot escape. After a brief period of vigorous activity the mice adopt a characteristic immobile posture which is readily identifiable. Immobility was reduced by tricyclic antidepressants, monoamine oxidase inhibitors and atypical antidepressants, as well as by electroconvulsive shock. Psychostimulants also reduced immobility but in contrast to antidepressants caused marked motor stimulation. Immobility was not affected by minor or major tranquilisers. These findings, closely parallel to those we have previously reported in rats, suggest that the procedure is selectively sensitive to antidepressant treatments. The mouse procedure is, however, more rapid and less costly than that with rats and is thus more suitable for the primary screening of antidepressant drugs.
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Antidepressant-like synergism of extracts from magnolia bark and ginger rhizome alone and in combination in mice.
TL;DR: Results demonstrated that HMM was the principal component of this drug pair, whereas OGR served as adjuvant fraction, and confirmed the rationality of drug pair in clinical application and provided a novel perspective in drug pair of TCM researches.
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Combined Effects of Three High-Energy Charged Particle Beams Important for Space Flight on Brain, Behavioral and Cognitive Endpoints in B6D2F1 Female and Male Mice.
Jacob Raber,Joy Yamazaki,Eileen Ruth S. Torres,Nicole S. Kirchoff,Keaton Stagaman,Thomas J. Sharpton,Mitchell S. Turker,Amy Kronenberg +7 more
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Antidepressant-like effect of essential oil of Perilla frutescens in a chronic, unpredictable, mild stress-induced depression model mice
Wei-Wei Ji,Rui-Peng Li,Meng Li,Shuyuan Wang,Xian Zhang,Xing-Xing Niu,Wei Li,Lu Yan,Yang Wang,Qiang Fu,Shi-Ping Ma +10 more
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SSRIs target prefrontal to raphe circuits during development modulating synaptic connectivity and emotional behavior
Mariano Soiza-Reilly,Mariano Soiza-Reilly,F J Meye,F J Meye,Jimmy Olusakin,Jimmy Olusakin,Ludovic Telley,E Petit,X Chen,Manuel Mameli,Manuel Mameli,Denis Jabaudon,J-Y Sze,Patricia Gaspar,Patricia Gaspar +14 more
TL;DR: It is demonstrated that developmental expression of SERT in this subset of PFC neurons controls synaptic maturation of P FC-to-DRN circuits, and that remodeling of these circuits in early life modulates behavioral responses to stress in adulthood.
The involvement of the GPR39-Zn(2+)-sensing receptor in the pathophysiology of depression. Studies in rodent models and suicide victims.
Katarzyna Młyniec,Katarzyna Młyniec,Urszula Doboszewska,Bernadeta Szewczyk,Magdalena Sowa-Kućma,Paulina Misztak,Wojciech Piekoszewski,Franciszek Trela,Beata Ostachowicz,Gabriel Nowak +9 more
TL;DR: Down-regulation of CREB, BDNF, TrkB and GPR39 receptor found under zinc-deficient conditions in the hippocampus, may play an important role in the pathophysiology of mood disorders, since most of patients suffering from depression show lower serum zinc.
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