Open AccessJournal Article
Behavioral despair in mice: a primary screening test for antidepressants
Porsolt Rd,Bertin A,Jalfre M +2 more
3.5K
TL;DR: The mouse procedure is more rapid and less costly than that with rats and is thus more suitable for the primary screening of antidepressant drugs, suggesting that the procedure is selectively sensitive to antidepressant treatments.
read more
Abstract: A depressed state can be induced in mice by forcing them to swim in a narrow cylinder from which they cannot escape. After a brief period of vigorous activity the mice adopt a characteristic immobile posture which is readily identifiable. Immobility was reduced by tricyclic antidepressants, monoamine oxidase inhibitors and atypical antidepressants, as well as by electroconvulsive shock. Psychostimulants also reduced immobility but in contrast to antidepressants caused marked motor stimulation. Immobility was not affected by minor or major tranquilisers. These findings, closely parallel to those we have previously reported in rats, suggest that the procedure is selectively sensitive to antidepressant treatments. The mouse procedure is, however, more rapid and less costly than that with rats and is thus more suitable for the primary screening of antidepressant drugs.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
Delayed physical and neurobehavioral development and increased aggressive and depression-like behaviors in the rat offspring of dams fed a high-fat diet.
Catherine Ássuka Giriko,Carla Albuquerque Andreoli,Laís Vales Mennitti,Lilian Fazion Hosoume,Tayane dos Santos Souto,Alexandre Valotta da Silva,Cristiano Mendes-da-Silva +6 more
TL;DR: Developmental and neurobehavioral changes in the rat offspring of dams fed the HFD during lactation are shown and possible disruption of physical and sensory‐motor maturation and increased susceptibility to depressive and aggressive‐like behavior is suggested.
74
Dynamic changes in hippocampal microglia contribute to depressive-like behavior induced by early social isolation.
Yu Gong,Lijuan Tong,Rongrong Yang,Wenfeng Hu,Xingguo Xu,Wang Wenjing,Peng Wang,Xu Lu,Minhui Gao,Yue Wu,Xing Xu,Yaru Zhang,Zhuo Chen,Chao Huang +13 more
TL;DR: Results reveal an etiological role of hippocampal microglia loss in ESI‐induced depression and demonstrate that the restoration of microglial homeostasis in the hippocampus may serve as a therapeutic strategy for depression induced by early‐life stress.
74
Enriched environment ameliorates depression-induced cognitive deficits and restores abnormal hippocampal synaptic plasticity.
TL;DR: This study convincingly proves that depression-induces learning deficits and impairs hippocampal synaptic plasticity, and highlights the role of environmental stimuli in restoring depression-induced cognitive deficits which might prove vital in outlining more effective strategies to treat major depressive disorders.
74
Is agmatine an endogenous anxiolytic/antidepressant agent?
Feyza Aricioglu,Hale Altunbas +1 more
TL;DR: As an endogenous substance, agmatine have modulatory effect on anxiety and depression, as compared with the saline group.
74
Antidepressant-like effect of lamotrigine in the mouse forced swimming test: Evidence for the involvement of the noradrenergic system
Manuella P. Kaster,Inara M. Raupp,Ricardo W. Binfaré,Roberto Andreatini,Ana Lúcia S. Rodrigues +4 more
TL;DR: The present study suggests that the antidepressant-like effect of lamotrigine in the forced swimming test is related to the noradrenergic system, likely due to an activation of alpha1- and alpha2-postsynaptic adrenoceptors.
74