Open AccessJournal Article
Behavioral despair in mice: a primary screening test for antidepressants
Porsolt Rd,Bertin A,Jalfre M +2 more
3.5K
TL;DR: The mouse procedure is more rapid and less costly than that with rats and is thus more suitable for the primary screening of antidepressant drugs, suggesting that the procedure is selectively sensitive to antidepressant treatments.
read more
Abstract: A depressed state can be induced in mice by forcing them to swim in a narrow cylinder from which they cannot escape. After a brief period of vigorous activity the mice adopt a characteristic immobile posture which is readily identifiable. Immobility was reduced by tricyclic antidepressants, monoamine oxidase inhibitors and atypical antidepressants, as well as by electroconvulsive shock. Psychostimulants also reduced immobility but in contrast to antidepressants caused marked motor stimulation. Immobility was not affected by minor or major tranquilisers. These findings, closely parallel to those we have previously reported in rats, suggest that the procedure is selectively sensitive to antidepressant treatments. The mouse procedure is, however, more rapid and less costly than that with rats and is thus more suitable for the primary screening of antidepressant drugs.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
Nociceptin receptor antagonists display antidepressant-like properties in the mouse forced swimming test.
TL;DR: It is suggested that nociceptin, and its receptor, may play a role in depressive disorders and that the nocICEptin system could represent a novel target for the development of new antidepressant drugs.
86
Intracerebroventricular administration of HIV-1 Tat induces brain cytokine and indoleamine 2,3-dioxygenase expression: A possible mechanism for AIDS comorbid depression
TL;DR: It is demonstrated that a single exposure to Tat in the brain is sufficient to induce brain cytokine signaling that culminates in depressive-like behavior.
Group housing of mice increases immobility and antidepressant sensitivity in the forced swim and tail suspension tests.
Beata Karolewicz,Ian A. Paul +1 more
TL;DR: The results indicate that both tests are sensitive to housing conditions and suggests that long lasting group housing may be critical to the behavioral response in these preclinical screening procedures in mice.
85
Endocannabinoid control of the insular-bed nucleus of the stria terminalis circuit regulates negative affective behavior associated with alcohol abstinence.
Samuel W. Centanni,Bridget D Morris,Joseph R. Luchsinger,Gaurav Bedse,Tracy L. Fetterly,Sachin Patel,Danny G. Winder +6 more
TL;DR: A role for the insular cortex (insula), a region involved in regulating interoception, as a dense, functional, eCB-sensitive input to the dBNST is identified and demonstrated, highlighting the therapeutic potential of the eCB system for treating negative affective disorders.
85
Psychopharmacological properties of calcium channel inhibitors.
TL;DR: The psychopharmacology of CCIs is reviewed, concentrating on preclinical data, but including supportive clinical and biochemical evidence as well, which focuses on these drugs' antidepressant, antidopaminergic (neuroleptic-like), anxiolytic and anticonvulsant effects.
85