Barrel cortex function

TL;DR: This work reveals sparse and spatially intermingled representations of multiple tactile features in mice expressing GCaMP6s and nuclear red fluorescent proteins during performance of a single whisker object localization task and an encoding model related activity to behavioral variables.

TL;DR: Early spontaneous activity patterns control the formation of developing networks in sensory cortices, and disturbances of these activity patterns may lead to long-lasting neuronal deficits.

TL;DR: The potential for the use of known critical and sensitive periods during vertebrate development to investigate and advance the understanding of the neural bases underlying impairments in these developmental disorders of the nervous system is highlighted.

TL;DR: Making whole-cell recordings in primary somatosensory barrel cortex of behaving mice shows that S1 neurons projecting to primary motor cortex and those projecting to secondary somatoensory cortex have distinct intrinsic membrane properties and exhibit markedly different membrane potential dynamics during behavior.

TL;DR: It is concluded that the structure and function of cortex honors two major computational principles: " just-enough" and "just-in-time."

TL;DR: It is found that horizontal projections suppress superficial layers while simultaneously activating deeper cortical output layers, and this layer-specific modulation does not result from a spatial separation of excitation and inhibition, but from a layer- specific ratio between these two opposing conductances.

TL;DR: Investigating the mouse whisker system, this work found an additional and equally direct pathway for cortical motor control driven by the primary somatosensory cortex, providing a rapid negative feedback signal for sensorimotor integration.

TL;DR: Choline acetyltransferase (ChAT), the acetylcholine‐synthesizing enzyme and a definitive marker for cholinergic neurons, was localized immunocytochemically in the motor and somatic sensory regions of rat cerebral cortex with monoclonal antibodies.