Journal Article10.1038/NRMICRO2315
Bacteriophage resistance mechanisms.
2.2K
TL;DR: This Review highlights the most important antiviral mechanisms of bacteria as well as the counter-attacks used by phages to evade these systems.
read more
Abstract: Phages are now acknowledged as the most abundant microorganisms on the planet and are also possibly the most diversified. This diversity is mostly driven by their dynamic adaptation when facing selective pressure such as phage resistance mechanisms, which are widespread in bacterial hosts. When infecting bacterial cells, phages face a range of antiviral mechanisms, and they have evolved multiple tactics to avoid, circumvent or subvert these mechanisms in order to thrive in most environments. In this Review, we highlight the most important antiviral mechanisms of bacteria as well as the counter-attacks used by phages to evade these systems.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
A guard-killer phage cocktail effectively lyses the host and inhibits the development of phage-resistant strains of Escherichia coli
Ling Yu,Shuang Wang,Zhimin Guo,Hongtao Liu,Diangang Sun,Guangmou Yan,Dongliang Hu,Dongliang Hu,Chongtao Du,Xin Feng,Wenyu Han,Jingmin Gu,Changjiang Sun,Liancheng Lei +13 more
TL;DR: Because the bacteriophage against the phage-resistant strain is an ideal guard that promptly attacks potential phage resistance, this guard-killer dual-function phage cocktail provides a novel strategy for phage therapy that allows the natural ecology to be sustained.
57
CRISPR Visualizer: rapid identification and visualization of CRISPR loci via an automated high-throughput processing pipeline.
TL;DR: A high-throughput extraction pipeline coupled with a local web-based visualization tool is constructed which enables CRISPR spacer and repeat extraction, rapid visualization, graphical comparison, and progressive multiple sequence alignment and supports accelerated analysis of genomic data sets.
57
Phage–Antibiotic Therapy as a Promising Strategy to Combat Multidrug-Resistant Infections and to Enhance Antimicrobial Efficiency
TL;DR: This review paper on the current progress of phage–antibiotic therapy includes aspects of the mechanisms of PAS and the therapeutic performance of PAs in combating multidrug-resistant bacterial infections.
The mannose phosphotransferase system (Man-PTS) - Mannose transporter and receptor for bacteriocins and bacteriophages.
TL;DR: Man-PTS are abundant in Gram-positive bacteria living on carbohydrate rich mucosal surfaces, and a subgroup of IICIID complexes serve as receptors for class IIa bacteriocins and as channel for the penetration of bacteriophage lambda DNA across the inner membrane.
56
The Age of Phage: Friend or Foe in the New Dawn of Therapeutic and Biocontrol Applications?
TL;DR: The potential of some bacteriophages to aid in the acquisition, maintenance, and dissemination of negatively associated bacterial genes, including resistance and virulence genes, through transduction is of concern and requires deeper understanding as mentioned in this paper.
55
References
CRISPR provides acquired resistance against viruses in prokaryotes
Rodolphe Barrangou,Christophe Fremaux,Hélène Deveau,Melissa Richards,Patrick Boyaval,Sylvain Moineau,Dennis A. Romero,Philippe Horvath +7 more
TL;DR: It is found that, after viral challenge, bacteria integrated new spacers derived from phage genomic sequences, and CRISPR provided resistance against phages, and resistance specificity is determined by spacer-phage sequence similarity.
Small CRISPR RNAs guide antiviral defense in prokaryotes
Stan J. J. Brouns,Matthijs M. Jore,Magnus Lundgren,Edze R. Westra,Rik J. H. Slijkhuis,Ambrosius P. Snijders,Mark J. Dickman,Kira S. Makarova,Eugene V. Koonin,John van der Oost +9 more
TL;DR: The results demonstrate that the formation of mature guide RNAs by the CRISPR RNA endonuclease subunit of Cascade is a mechanistic requirement for antiviral defense.
CRISPR/Cas, the Immune System of Bacteria and Archaea
TL;DR: Clustered regularly interspaced short palindromic repeats (CRISPR) form peculiar genetic loci, which provide acquired immunity against viruses and plasmids by targeting nucleic acid in a sequence-specific manner.
2.5K
Nucleotide sequence of the iap gene, responsible for alkaline phosphatase isozyme conversion in Escherichia coli, and identification of the gene product.
TL;DR: Neither the isozyme-converting activity nor labeled Iap proteins were detected in the osmotic-shock fluid of cells carrying a multicopy iap plasmid, and the Iap protein seems to be associated with the membrane.
2.2K
Intervening Sequences of Regularly Spaced Prokaryotic Repeats Derive from Foreign Genetic Elements
TL;DR: It is shown that CRISPR spacers derive from preexisting sequences, either chromosomal or within transmissible genetic elements such as bacteriophages and conjugative plasmids, implying a relationship betweenCRISPR and immunity against targeted DNA.
2.1K