Journal Article10.1177/039139880703000903
Bacterial communications in implant infections: a target for an intelligence war.
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TL;DR: Attenuation of bacterial virulence by quorum-sensing inhibitors, rather than by bactericidal or bacteriostatic drugs, is a highly attractive concept because these antibacterial agents are less likely to induce the development of bacterial resistance.
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Abstract: The status of population density is communicated among bacteria by specific secreted molecules, called pheromones or autoinducers, and the control mechanism is called “quorum-sensing” Quorum-sensi
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Citations
Biofilm formation in Staphylococcus implant infections. A review of molecular mechanisms and implications for biofilm-resistant materials.
Carla Renata Arciola,Davide Campoccia,Pietro Speziale,Lucio Montanaro,John William Costerton +4 more
TL;DR: Advances in scientific knowledge on structural molecules, proteins, teichoic acids, and the most recently described extracellular DNA, on the synthesis and genetics of staphylococcal biofilms, and on the complex network of signal factors that intervene in their control are presented are presented, also reporting on the emerging strategies to disrupt or inhibit them.
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Bacterial Biofilms: Development, Dispersal, and Therapeutic Strategies in the Dawn of the Postantibiotic Era
TL;DR: A general review of the steps leading to biofilm formation on surfaces and within eukaryotic cells is provided, highlighting several medically important pathogens, and recent advances on novel strategies aimed at biofilm prevention and/or dissolution are discussed.
Antimicrobial susceptibility testing in biofilm-growing bacteria
TL;DR: Standardization of the procedures, parameters and breakpoints, by official agencies, is needed before they are implemented in clinical microbiology laboratories for routine susceptibility testing, to obtain a deeper understanding of biofilm resistance mechanisms.
490
Prevention and control of biofilm-based medical-device-related infections
TL;DR: The most successful approaches for the control and prevention of healthcare-associated infections as well as promising perspectives for the development of novel devices refractory to microbial adhesion, colonization and biofilm formation are reviewed.
475
Polysaccharide intercellular adhesin in biofilm: structural and regulatory aspects.
TL;DR: A role is played by the quorum sensing system, which negatively regulates biofilm formation, favoring the dispersal phase that disseminates bacteria to new infection sites, and Interfering with the QS system is a much debated strategy to combat biofilm-related infections.
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Attenuation of Pseudomonas aeruginosa virulence by quorum sensing inhibitors
Morten Hentzer,Hong Wu,Jens Bo Andersen,Kathrin Riedel,Thomas Bovbjerg Rasmussen,Niels Bagge,Naresh Kumar,Mark A. Schembri,Zhijun Song,Peter Kristoffersen,Mike Manefield,J. W. Costerton,Søren Molin,Leo Eberl,Peter D. Steinberg,Staffan Kjelleberg,Niels Høiby,Michael Givskov +17 more
TL;DR: A synthetic derivate of natural furanone compounds can act as a potent antagonist of bacterial quorum sensing and inhibited virulence factor expression in a mouse pulmonary infection model.
Autoinduction and signal transduction in the regulation of staphylococcal virulence
TL;DR: This review is an attempt to integrate a large body of data into the beginnings of a model that will hopefully help to guide research towards a full‐scale test of the regulatory agenda of Staphylococcus aureus.
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Identification, Timing, and Signal Specificity of Pseudomonas aeruginosa Quorum-Controlled Genes: a Transcriptome Analysis
TL;DR: It is suggested that the level of the signal receptor, LasR, is a critical trigger for quorum-activated gene expression, and acyl-homoserine lactone quorum sensing appears to be a system that allows ordered expression of hundreds of genes during P. aeruginosa growth in culture.
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