Journal Article10.1016/j.mex.2023.102414
Auditory brainstem response (ABR) waveform analysis program
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TL;DR: The goal of developing this program was to make a user-friendly semiautomatic peak-detection algorithm to encourage widespread analysis of the amplitudes and latencies of the ABR, which may yield informative details about the integrity of the auditory system with development, aging, genetic manipulations, or damaging conditions.
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Abstract: Auditory brainstem responses (ABR) are a high-throughput assessment of auditory function. Many studies determine changes to the threshold at frequencies that span the normal hearing range of their test subjects, but fewer studies evaluate changes in waveform morphology. The goal of developing this program was to make a user-friendly semiautomatic peak-detection algorithm to encourage widespread analysis of the amplitudes and latencies of the ABR, which may yield informative details about the integrity of the auditory system with development, aging, genetic manipulations, or damaging conditions. This method incorporates automated peak detection with manual override and inter-rater validation to calculate the amplitude and latency for waves 1-5, as well as interpeak latencies and amplitude ratios between waves. The output includes raw data and calculations in a format compatible with graphical and statistical software.•The method yields a high-throughput peak-detection algorithm with manual override and inter-rater capabilities to streamline ABR waveform analysis.•Data output includes amplitudes, latencies, amplitude ratios, and interpeak latencies for generation of input-output curves.•While complete automation of peak detection with this tool is dependent on good signal-to-noise ratios, relevant amplitude and latency calculations are fully automated, and manual spot-checking is simplified to significantly reduce the time to analyze waveforms.
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Citations
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References
Adding Insult to Injury: Cochlear Nerve Degeneration after “Temporary” Noise-Induced Hearing Loss
TL;DR: It is shown that acoustic overexposures causing moderate, but completely reversible, threshold elevation leave cochlear sensory cells intact, but cause acute loss of afferent nerve terminals and delayed degeneration of the co chlear nerve.
2.3K
Tinnitus with a normal audiogram: physiological evidence for hidden hearing loss and computational model.
Roland Schaette,David McAlpine +1 more
TL;DR: It is reported that in human subjects with tinnitus and a normal audiogram, auditory brainstem responses show a significantly reduced amplitude of the wave I potential but normal amplitudes of the more centrally generated wave V.
962
Assessment of hearing in 80 inbred strains of mice by ABR threshold analyses.
TL;DR: A large-scale, auditory screening project is being undertaken at The Jackson Laboratory (TJL) to identify mice with inherited hearing disorders, and this large database establishes a reliable reference for normal hearing mouse strains.
858
Age-related cochlear synaptopathy: an early-onset contributor to auditory functional decline.
Y. Sergeyenko,K. Lall,K. Lall,M. C. Liberman,M. C. Liberman,Sharon G. Kujawa,Sharon G. Kujawa,Sharon G. Kujawa +7 more
TL;DR: Age-related cochlear synaptic and neural degeneration in CBA/CaJ mice never exposed to high-level noise is characterized and key functional clues to the synaptopathy are available in the neural response; these can be accessed noninvasively, enhancing the possibilities for translation to human clinical characterization.
758
Synaptopathy in the noise-exposed and aging cochlea: Primary neural degeneration in acquired sensorineural hearing loss
TL;DR: The research suggests that primary neural degeneration is an important contributor to the perceptual handicap in SNHL, and in cases where the hair cells survive, neurotrophin therapies can elicit neurite outgrowth from spiral ganglion neurons and re-establishment of their peripheral synapses.
714