Journal Article10.1016/J.NEUROSCIENCE.2005.10.051
AT4 receptor activation increases intracellular calcium influx and induces a non-N-methyl-d-aspartate dependent form of long-term potentiation
Christopher J. Davis,Enikö A. Kramár,Alok De,Peter C. Meighan,Steven M. Simasko,John W. Wright,Joseph W. Harding +6 more
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TL;DR: Data indicate that increased calcium influx through postsynaptic calcium channels contribute to Norleucine1-angiotensin IV-induced enhancement of long-term potentiation, and suggests that AT4 receptor activation increases intracellular calcium levels via altering voltage dependent calcium channels and triggers an N-methyl-D-aspartate-independent form ofLong- term potentiation.
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About: This article is published in Neuroscience. The article was published on 01 Jan 2006. The article focuses on the topics: Norleucine & T-type calcium channel.
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Citations
Within the Brain: The Renin Angiotensin System.
Ladonya Jackson,Wael Eldahshan,Susan C. Fagan,Susan C. Fagan,Adviye Ergul,Adviye Ergul,Adviye Ergul +6 more
TL;DR: In this review, the preclinical and clinical evidence for the impact of RAS modulators on cognitive impairment of multiple etiologies will be discussed and the expression and function of different receptor subtypes within the RAS, on different cell types within the brain are presented.
300
The CNS renin-angiotensin system
TL;DR: The renin-angiotensin system of the brain is involved not only in theregulation of blood pressure, but also in the modulation of multiple additional functions in the brain, including processes of sensory information, learning, and memory, and the regulation of emotional responses.
252
The brain renin–angiotensin system: a diversity of functions and implications for CNS diseases
John W. Wright,Joseph W. Harding +1 more
TL;DR: This review first describes the enzymatic pathways resulting in active angiotensin ligands and their interaction with AT1, AT2, and AT4 receptor subtypes and discusses the classic physiologies and behaviors controlled by the RAS including cardiovascular, thirst, and sodium appetite.
205
Angiotensin type 1 receptor antagonist losartan, reduces MPTP-induced degeneration of dopaminergic neurons in substantia nigra
Tom N. Grammatopoulos,Susan M. Jones,Ferogh A. Ahmadi,Brian R Hoover,Lawrence D. Snell,Jesse Skoch,Vimal V Jhaveri,Andy M. Poczobutt,James A. Weyhenmeyer,W. Michael Zawada +9 more
TL;DR: It is shown that an antagonist of the angiotensin II (Ang II) type 1 (AT1) receptor, losartan, protects dopaminergic neurons against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) toxicity both in primary ventral mesencephalic cultures as well as in the substantia nigra pars compacta of C57BL/6 mice.
Brain Renin-Angiotensin System at the Intersect of Physical and Cognitive Frailty.
Çağlar Coşarderelioğlu,Lolita S. Nidadavolu,Claudene J. George,Esther S. Oh,David A. Bennett,Jeremy D. Walston,Peter M. Abadir +6 more
TL;DR: The relationships among brain RAS, aging, frailty, and specific neurodegenerative diseases, such as Alzheimer’s disease, Parkinson's disease, and vascular cognitive impairment, are focused on through oxidative stress, neuroinflammation, andascular dysfunction.
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