Journal Article10.1089/GTMB.2013.0441
Association between the g.14461A>G genetic polymorphism of the TLR4 gene and type 2 diabetes mellitus risk in a Chinese population.
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TL;DR: Investigation of the association between the TLR4 gene polymorphisms and type 2 diabetes mellitus susceptibility indicated that the g.14461A>G genetic polymorphism was significantly associated with the increased susceptibility to T2DM.
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Abstract: Objective: Toll-like receptor 4 (TLR4) is an important candidate gene for mediating the susceptibility to type 2 diabetes mellitus (T2DM). The purpose of this study was to investigate the association between the TLR4 gene polymorphisms and T2DM susceptibility. Methods: A total of 671 T2DM patients and 677 healthy controls were recruited in this study. The created restriction site–polymerase chain reaction and DNA sequencing methods have been used to analyze the TLR4 gene polymorphisms. Results: One novel genetic polymorphism (g.14461A>G) was found. Our data indicated that the g.14461A>G genetic polymorphism was significantly associated with the increased susceptibility to T2DM in a homozygote comparison (GG vs. AA: odds ratio [OR]=2.09, 95% confidence interval [CI] 1.44–3.04, p<0.001), dominant model (GG/AG vs. AA: OR=1.27, 95% CI 1.03–1.57, p=0.028), recessive model (GG vs. AG/AA: OR=1.98, 95% CI 1.39–2.83, p<0.001), and allele contrast (G vs. A: OR=1.33, 95% CI 1.13–1.57, p=0.001). The allele-G might be...
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Citations
Association of TLR4 gene polymorphisms with susceptibility to type 2 diabetes mellitus in the Chinese Han population.
TL;DR: Preliminary findings indicate that the g.13726T>C and g.15090G>A genetic polymorphisms of TLR4 gene are potentially related to the susceptibility to T2DM in the studied population, and might be used as molecular markers for evaluating the risk of T2 DM.
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Interactions of TRAF6 and NLRX1 gene polymorphisms with environmental factors on the susceptibility of type 2 diabetes mellitus vascular complications in a southern Han Chinese population
Chengli Zeng,Zixing Zhou,Yajing Han,Zihao Wen,Congcong Guo,Shiqi Huang,Di Xiao,Xiaohong Ye,Meiling Ou,Chuican Huang,Xingguang Ye,Guang Yang,Chunxia Jing,Lihong Nie +13 more
TL;DR: Evidence is provided that the NLRX1 rs4245191 polymorphisms influence the risk of T2DM macrovascular complications and diabetic cerebral infarction, and there are no significant differences in haplotypes, gene-gene interactions and gene-environment interactions among T2 DM vascular subgroup patients.
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