Journal Article10.1016/J.MEHY.2009.02.025
Association between human papillomavirus and Epstein-Barr virus infections in human oral carcinogenesis.
Prof. Ala-Eddin Al Moustafa,Prof. Ala-Eddin Al Moustafa,Dongfeng Chen,Lina Ghabreau,Nizar Akil +4 more
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TL;DR: The hypothesis that human oral normal epithelial cells, especially nasopharyngeal cells, are very susceptible to persistent HPV and EBV co-infections and play an important role in the initiation of a neoplastic transformation of human oral epithelial Cells is proposed.
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About: This article is published in Medical Hypotheses. The article was published on 01 Aug 2009. The article focuses on the topics: Neoplastic transformation & Population.
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Citations
Oral Cancer: Risk Factors and Molecular Pathogenesis
TL;DR: Current development of molecular picture of pathoprogression and molecular genetic tools opens the avenue for easier diagnosis, better prognostication and efficient therapeutic management.
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•Journal Article
Human papilloma virus, herpes simplex virus and epstein barr virus in oral squamous cell carcinoma from eight different countries.
Jamshid Jalouli,Miranda M. Jalouli,Dipak Sapkota,Salah O. Ibrahim,Per-Anders Larsson,Lars Sand +5 more
TL;DR: The prevalence of human papillomaviruses, herpes simplex virus and Epstein-Barr virus was investigated in 155 oral squamous cell carcinoma patients from eight different countries from different ethnic groups, continents and with different socioeconomic backgrounds, and no firm conclusions could be drawn regarding the relationship between alcohol, tobacco and virus infections.
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High-risk human papillomavirus in nasopharyngeal carcinoma
TL;DR: Human papillomavirus (HPV), a cause of oropharyngeal carcinoma, has also been implicated as an etiologic agent in nasopharyngeAL carcinomas.
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Coinfection with Epstein-Barr Virus (EBV), Human Papilloma Virus (HPV) and Polyoma BK Virus (BKPyV) in Laryngeal, Oropharyngeal and Oral Cavity Cancer
TL;DR: A significant correlation was observed between tumour dimensions (T) and lymph-node involvement (N) in co-infected patients compared to single infection, and it is necessary to clarify whether co- Infection plays an important role in the initiation and/or progression of oncogenic transformation of oral, oropharyngeal and laryngeAL epithelial cells.
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Multiple infections and cancer: implications in epidemiology.
TL;DR: The role of infectious agents in malignancies is discussed, the role of multiple/co-infections in cancer etiology is highlighted, and implications for cancer epidemiology are reviewed.
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References
HPV in oral squamous cell carcinoma vs head and neck squamous cell carcinoma biopsies: a meta-analysis (1988-2007)
Nicoletta Termine,Vera Panzarella,Silvia Falaschini,Silvia Falaschini,Antonio Russo,Domenica Matranga,Lorenzo Lo Muzio,Giuseppina Campisi +7 more
TL;DR: Findings support the assumption that a correct distinction of HNSCC by site, together with the use of more sensitive HPV DNA detection methods, should be considered as essential prerogatives in designing future investigations into viral prevalence in head and neck tumors.
Consistent transcription of the Epstein-Barr virus LMP2 gene in nasopharyngeal carcinoma.
TL;DR: Two species of the Epstein-Barr virus-encoded latent membrane protein 2 (LMP2A and LMP2B) are generated by alternative splicing, each species having a distinct first exon LMP 2 transcription in undifferentiated nasopharyngeal carcinoma (NPC).
Detection of Epstein-Barr virus (EBV) in hepatocellular carcinoma tissue: a novel EBV latency characterized by the absence of EBV-encoded small RNA expression.
Yasuhiko Sugawara,Yuzo Mizugaki,Toshikazu Uchida,Tetsuo Torii,Shosuke Imai,Masatoshi Makuuchi,Kenzo Takada +6 more
TL;DR: The results indicated that there is a high EBV load in H CC tissue and that all of the HCC tissue examined showed a novel pattern of EBV latency characterized by absence ofEBV-encoded small RNA expression.
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