Journal Article10.1016/J.MEHY.2009.02.025
Association between human papillomavirus and Epstein-Barr virus infections in human oral carcinogenesis.
Prof. Ala-Eddin Al Moustafa,Prof. Ala-Eddin Al Moustafa,Dongfeng Chen,Lina Ghabreau,Nizar Akil +4 more
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TL;DR: The hypothesis that human oral normal epithelial cells, especially nasopharyngeal cells, are very susceptible to persistent HPV and EBV co-infections and play an important role in the initiation of a neoplastic transformation of human oral epithelial Cells is proposed.
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About: This article is published in Medical Hypotheses. The article was published on 01 Aug 2009. The article focuses on the topics: Neoplastic transformation & Population.
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Citations
Oral Cancer: Risk Factors and Molecular Pathogenesis
TL;DR: Current development of molecular picture of pathoprogression and molecular genetic tools opens the avenue for easier diagnosis, better prognostication and efficient therapeutic management.
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•Journal Article
Human papilloma virus, herpes simplex virus and epstein barr virus in oral squamous cell carcinoma from eight different countries.
Jamshid Jalouli,Miranda M. Jalouli,Dipak Sapkota,Salah O. Ibrahim,Per-Anders Larsson,Lars Sand +5 more
TL;DR: The prevalence of human papillomaviruses, herpes simplex virus and Epstein-Barr virus was investigated in 155 oral squamous cell carcinoma patients from eight different countries from different ethnic groups, continents and with different socioeconomic backgrounds, and no firm conclusions could be drawn regarding the relationship between alcohol, tobacco and virus infections.
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High-risk human papillomavirus in nasopharyngeal carcinoma
TL;DR: Human papillomavirus (HPV), a cause of oropharyngeal carcinoma, has also been implicated as an etiologic agent in nasopharyngeAL carcinomas.
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Coinfection with Epstein-Barr Virus (EBV), Human Papilloma Virus (HPV) and Polyoma BK Virus (BKPyV) in Laryngeal, Oropharyngeal and Oral Cavity Cancer
TL;DR: A significant correlation was observed between tumour dimensions (T) and lymph-node involvement (N) in co-infected patients compared to single infection, and it is necessary to clarify whether co- Infection plays an important role in the initiation and/or progression of oncogenic transformation of oral, oropharyngeal and laryngeAL epithelial cells.
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Multiple infections and cancer: implications in epidemiology.
TL;DR: The role of infectious agents in malignancies is discussed, the role of multiple/co-infections in cancer etiology is highlighted, and implications for cancer epidemiology are reviewed.
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References
Homologous sequences in adenovirus E1A and human papillomavirus E7 proteins mediate interaction with the same set of cellular proteins.
TL;DR: It is shown that short synthetic peptides containing the pRB-binding sequences of E1A are sufficient for interaction with p107, cyclin A, and p130, suggesting that the common mechanism of transformation used by these viral oncogenes involves their association with a set of polypeptides.
The role of Epstein-Barr virus in cancer.
Samuel B Pattle,Paul J. Farrell +1 more
TL;DR: The contributions that the virus may play in different types of human cancer, particularly Burkitt's lymphoma, Hodgkin’s lymphomas, lymphomas and lymphoproliferative diseases in the immunocompromised, and nasopharyngeal and gastric carcinoma are focused on.
Regulation of the cell cycle by viral oncoproteins
TL;DR: Human papillomavirus and simian virus 40 are small DNA viruses which can show oncogenic activity and their interactions with the cell encoded pRB and p53 proteins, products of tumour suppressor genes, are of particular interest.
•Journal Article
Strong correlation between c-erbB-2 overexpression and overall survival of patients with oral squamous cell carcinoma.
Weiya Xia,Yiu Keung Lau,Hua Zhong Zhang,Ai Ru Liu,Lei Li,Nobutaka Kiyokawa,Gary L. Clayman,Ruth L. Katz,Mien Chie Hung +8 more
TL;DR: It is concluded that overexpression of c-erbB-2 is a frequent event in oral SCC and is correlated with poor survival and may be used as a poor prognostic factor.
Epstein-Barr virus latent membrane protein 2A is a B-cell receptor mimic and essential for B-cell survival
TL;DR: It is shown that LMP2A is essential for growth transformation of germinal center B cells, which do not express the genuine BCR because of deleterious somatic hypermutations in their immunoglobulin genes and point to its role as an indispensable BCR mimic in certain B cells from which human B-cell tumors such as Hodgkin lymphoma originate.
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