Journal Article10.1016/J.JAD.2019.08.014
Association between fecal microbiota and generalized anxiety disorder: Severity and early treatment response.
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TL;DR: Gut microbiome compositions were altered in A-GAD patients, with fewer operational taxonomic units and lower fecal bacterial α-diversity, which may contribute to GAD pathogenesis and remission.
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About: This article is published in Journal of Affective Disorders. The article was published on 01 Dec 2019. The article focuses on the topics: Hamilton Anxiety Rating Scale & Anxiety.
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Citations
The gut microbiota and mental health in adults
TL;DR: The heterogeneity between studies precludes conclusions regarding differences in microbiota composition in mental disease and health and many of the studies are limited by a cross-sectional design, small sample sizes and multiple comparisons, so well-designed longitudinal studies with larger sample size, accounting for confounders are needed.
144
Guts Imbalance Imbalances the Brain: A Review of Gut Microbiota Association With Neurological and Psychiatric Disorders
TL;DR: This study reviews recent research on the link between gut microbiota and the brain, and microbiome’s role in shaping the development of the most common neurological and psychiatric illnesses and considers the use of probiotic formulations as a potential non-invasive therapeutic opportunity for prevention and management of neuropsychiatric-associated affections.
138
Gut microbiota from persons with attention-deficit/hyperactivity disorder affects the brain in mice.
Anouk C. Tengeler,Sarita A. Dam,Maximilian Wiesmann,Jilly Naaijen,Miranda van Bodegom,Clara Belzer,Pieter J. Dederen,Vivienne Verweij,Barbara Franke,Tamas Kozicz,Tamas Kozicz,Alejandro Arias Vasquez,Amanda J. Kiliaan +12 more
TL;DR: It is demonstrated that altered microbial composition could be a driver of altered brain structure and function and concomitant changes in the animals’ behavior and may help to understand the mechanisms through which the gut microbiota contributes to the pathobiology of neurodevelopmental disorders.
107
Social isolation alters behavior, the gut-immune-brain axis, and neurochemical circuits in male and female prairie voles.
Meghan Donovan,Meghan Donovan,Meghan Donovan,Calvin S. Mackey,Grayson N. Platt,Jacob Rounds,Amber Brown,Darryl J. Trickey,Yan Liu,Kathryn M. Jones,Zuoxin Wang +10 more
TL;DR: The data suggest that social isolation alters the gut-immune-brain axis in a sex-dependent manner and that gut microbes, central glial cells, and neurochemical systems may play a critical, integrative role in mediating negative outcomes from social isolation.
106
Gut microbes in neurocognitive and mental health disorders
TL;DR: Understanding of the involvement of the gut microbiota in the pathophysiology of neurocognitive and mental health disorders can open up the need for a gut related approach in these disorders as well as unlock the door for the role of gut related microbiota management.
92
References
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
Javier A. Bravo,Paul Forsythe,Marianne V. Chew,Emily Escaravage,Hélène M. Savignac,Timothy G. Dinan,John Bienenstock,John F. Cryan +7 more
TL;DR: Chronic treatment with L. rhamnosus induced region-dependent alterations in GABAB1b mRNA in the brain with increases in cortical regions and concomitant reductions in expression in the hippocampus, amygdala, and locus coeruleus, in comparison with control-fed mice, highlighting the important role of bacteria in the bidirectional communication of the gut–brain axis.
3.4K
•Journal Article
The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems
TL;DR: This review summarizes the available evidence supporting the existence of microbiota-GBA interactions, as well as the possible pathophysiological mechanisms involved, and describes the importance of gut microbiota in influencing these interactions.
Gut-brain axis: how the microbiome influences anxiety and depression
TL;DR: Recent findings showing that microbiota are important in normal healthy brain function are reviewed, and ongoing and future animal and clinical studies aimed at understanding the microbiota-gut-brain axis may provide novel approaches for prevention and treatment of mental illness.
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Altered fecal microbiota composition in patients with major depressive disorder
Hai-yin Jiang,Zongxin Ling,Yong-Hua Zhang,Hongjin Mao,Zhanping Ma,Yan Yin,Weihong Wang,W.H. Wilson Tang,Zhonglin Tan,Jianfei Shi,Lanjuan Li,Bing Ruan +11 more
TL;DR: Fecal samples from 46 patients with depression are analyzed to enable a better understanding of changes in the fecal microbiota composition in such patients, showing either a predominance of some potentially harmful bacterial groups or a reduction in beneficial bacterial genera.
The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner
Gerard Clarke,Sue Grenham,Paul Scully,Patrick Fitzgerald,Rachel D. Moloney,Fergus Shanahan,Timothy G. Dinan,John F. Cryan +7 more
TL;DR: It is demonstrated that CNS neurotransmission can be profoundly disturbed by the absence of anormal gut microbiota and that this aberrant neurochemical, but not behavioural, profile is resistant to restoration of a normal gut flora in later life.
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