Association between different morphological types and abnormal karyotypes in early pregnancy loss
TL;DR: To identify the abnormal transvaginal ultrasound (TVS) findings typical of aneuploidic pregnancies that end with early pregnancy loss (EPL), a novel approach is proposed to quantify the importance of these findings in diagnosis and prognosis.
read more
Abstract: Objectives
To identify the abnormal transvaginal ultrasound (TVS) findings typical of aneuploidic pregnancies that end with early pregnancy loss (EPL).
Methods
This was a prospective clinical trial over a 2½-year period from January 2004 to June 2006 at the University Hospital of Cagliari, Italy. One hundred and fifty-six singleton pregnancies with EPL were evaluated by TVS, both before and at the moment of EPL diagnosis. Fetal karyotyping was performed on products of conception using microsatellite analysis to exclude maternal contamination in 46,XX cases. The proportions of abnormal karyotypes were compared among different groups of EPLs characterized by different morphological features.
Results
Six morphological types were identified in EPLs, one normal and five abnormal (small gestational sac, small embryo/fetus, early symmetrical arrested growth, enlarged yolk sac and empty sac). The highest rate of chromosomal abnormalities was observed in the early symmetrical arrested growth group (100%), followed by small embryo/fetus (94.1%), enlarged yolk sac (93.3%) and empty sac (72.2%) groups. The majority of cases of trisomy 22 (92.3%) were in the enlarged yolk sac group and the majority of cases with a 45,X karyotype were in the small embryo/fetus group (77.8%).
Conclusions
There is an association in EPLs between some abnormal karyotypes and some morphological types. The demonstration by TVS of abnormalities in the development of early pregnancy structures could be helpful for predicting aneuploidy in EPLs. Copyright © 2011 ISUOG. Published by John Wiley & Sons, Ltd.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
Differentiation of genetic abnormalities in early pregnancy loss
Stephanie Romero,K. B. Geiersbach,Christian N. Paxton,Nancy C. Rose,Enrique F. Schisterman,D. W. Branch,Robert M. Silver +6 more
TL;DR: This work has characterized the types of genetic abnormalities and their prevalence in early pregnancy loss at different developmental stages and hypothesized that the prevalence of genetic abnormality would differ across developmental stages.
66
Cytogenetic and morphological analysis of early products of conception following hystero-embryoscopy from couples with recurrent pregnancy loss
Caroline Robberecht,Anne Pexsters,Jan Deprest,Jean-Pierre Fryns,Thomas D'Hooghe,Joris Vermeesch +5 more
TL;DR: It is hypothesized that (recurrent) early pregnancy losses might have other genetic causes, including aneuploidies, that account for less than half of recurrent spontaneous abortions.
49
Miscarriage in contemporary maternal-fetal medicine: targeting clinical dilemmas.
TL;DR: Under certain conditions specified in the law, libraries and archives are authorized to furnish a photocopy or other reproduction, but the photocopy is not to be "used for any purpose other than private study, scholarship, or research".
29
Correlation between chromosomal distribution and embryonic findings on ultrasound in early pregnancy loss after IVF-embryo transfer.
TL;DR: The results are important because they call attention to the fact that EPLs that occur after implantation but prior to embryo formation frequently have normal karyotypes, and the non-normal distribution and non-homogeneous variances caused by limited cases of some rare chromosomal abnormalities.
20
References
Incidence of Early Loss of Pregnancy
Allen J. Wilcox,Clarice R. Weinberg,John O'Connor,Donna D. Baird,John Schlatterer,Robert E. Canfield,E G Armstrong,Bruce C. Nisula +7 more
TL;DR: The total rate of pregnancy loss after implantation, including clinically recognized spontaneous abortions, was 31 percent and most of the 40 women with unrecognized early pregnancy losses had normal fertility, since 95 percent of them subsequently became clinically pregnant within two years.
2.1K
UK multicentre project on assessment of risk of trisomy 21 by maternal age and fetal nuchal-translucency thickness at 10-14 weeks of gestation
TL;DR: Assessment of risk by a combination of maternal age and fetal nuchal-translucency thickness, measured by ultrasonography at 10-14 weeks of gestation, finds that selection of the high-risk group for invasive testing by this method allows the detection of about 80% of affected pregnancies.
1.6K
Estimates of human fertility and pregnancy loss.
TL;DR: The concept that the efficiency of human reproduction is maximum at approximately 30% per cycle is supported, with a very significant number of these pregnancies end in spontaneous abortion.
559
Anatomic and chromosomal anomalies in 639 spontaneous abortuses
TL;DR: A total of 639 spontaneous abortuses collected in a maternity hospital were set up in culture and successful karyotyping was done on 447 abortuses, of which 339 were studied with banding.
248
US Public Health Service sets out plan for xenotransplantation.
TL;DR: Gro Harlem Brundtland will take over the post of head of the World Health Organization (WHO) on July 21, and emphasised WHO’s duty towards the developing world.
205