Journal Article10.1056/NEJM199512283332604
Association between Bacterial Vaginosis and Preterm Delivery of a Low-Birth-Weight Infant
Sharon L. Hillier,Robert P. Nugent,David A. Eschenbach,Marijane A. Krohn,Ronald S. Gibbs,David H. Martin,Mary Frances Cotch,Robert R. Edelman,J G Pastorek nd,A V Rao +9 more
TL;DR: The women with bacterial vaginosis were more likely to be unmarried, to be black, to have low incomes, and to have previously delivered low-birth-weight infants.
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Abstract: Background Bacterial vaginosis is believed to be a risk factor for preterm delivery. We undertook a study of the association between bacterial vaginosis and the preterm delivery of infants with low birth weight after accounting for other known risk factors. Methods In this cohort study, we enrolled 10,397 pregnant women from seven medical centers who had no known medical risk factors for preterm delivery. At 23 to 26 weeks' gestation, bacterial vaginosis was determined to be present or absent on the basis of the vaginal pH and the results of Gram's staining. The principal outcome variable was the delivery at less than 37 weeks' gestation of an infant with a birth weight below 2500 g. Results Bacterial vaginosis was detected in 16 percent of the 10,397 women. The women with bacterial vaginosis were more likely to be unmarried, to be black, to have low incomes, and to have previously delivered low-birth-weight infants. In a multivariate analysis, the presence of bacterial vaginosis was related to preterm de...
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Citations
The influence of bacterial vaginosis on gestational week of the completion of delivery and biochemical markers of inflammation in the serum.
Ana Jakovljevic,Mirjana Bogavac,Aleksandra Nikolic,Mirjana Milošević Tošić,Zoran Novakovic,Zoran Stajic +5 more
TL;DR: The study indicates that the pregnancy complicated with bacterial vaginosis ends much earlier than the pregnancy without it and higher levels of biochemical markers of inflammation in the serum in the study group suggest that pathophysiological processes responsible for preterm delivery can begin very early in pregnancy.
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Advances in Research on the Relationship between Vaginal Microbiota and Adverse Pregnancy Outcomes and Gynecological Diseases
TL;DR: In this paper , the authors provide a comprehensive account of the normal vaginal microbiota, the association between the vaginal microbiota and pregnancy outcomes, and the impact of the vaginal microbial ecosystem on gynecological diseases in women.
Genome Sequences of 15 Gardnerella vaginalis Strains Isolated from the Vaginas of Women with and without Bacterial Vaginosis
Lloyd S. Robinson,Justin S. A. Perry,Sai Lek,Aye Wollam,Erica Sodergren,George M. Weinstock,Warren G. Lewis,Amanda L. Lewis +7 more
TL;DR: The draft genome sequences of 15 Gardnerella vaginalis strains isolated from women with and without bacterial vaginosis are presented and a dysbiosis of the vagina is associated with adverse health outcomes, including preterm birth.
Composition of Vaginal Microbiota in Pregnant Women With Aerobic Vaginitis.
Kwan Young Oh,Sung-Hee Lee,Myung-Shin Lee,Myung-Ju Lee,Eunjung Shim,Yun Ha Hwang,Joong Gyu Ha,Yun Seok Yang,In Taek Hwang,Jun Sook Park +9 more
TL;DR: In this paper, the authors analyzed the composition of the vaginal microbiota of pregnant women with AV using microbial community analysis and identified the causative organism using each criterion of the AV scoring system, and compared the quantification of aerobic bacteria using quantitative polymerase chain reaction (qPCR) and their relative abundances using metagenomics.
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TL;DR: In this article, the role of infection in prematurity was investigated in women who delivered prematurely and compared with those who delivered at term, using demographic and obstetrical characteristics, chorioamnionic cultures, and placental histologic features.
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