Journal Article10.1038/NM1467
Artificially engineered magnetic nanoparticles for ultra-sensitive molecular imaging.
Jae Hyun Lee,Yong Min Huh,Young-wook Jun,Jung Wook Seo,Jung Tak Jang,Ho Taek Song,Sungjun Kim,Eun Jin Cho,Ho-Geun Yoon,Jin Suck Suh,Jinwoo Cheon +10 more
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TL;DR: These magnetism-engineered iron oxide (MEIO) nanoprobes, when conjugated with antibodies, showed enhanced magnetic resonance imaging (MRI) sensitivity for the detection of cancer markers compared with probes currently available and could enhance the ability to visualize other biological events critical to diagnostics and therapeutics.
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Abstract: Successful development of ultra-sensitive molecular imaging nanoprobes for the detection of targeted biological objects is a challenging task Although magnetic nanoprobes have the potential to perform such a role, the results from probes that are currently available have been far from optimal Here we used artificial engineering approaches to develop innovative magnetic nanoprobes, through a process that involved the systematic evaluation of the magnetic spin, size and type of spinel metal ferrites These magnetism-engineered iron oxide (MEIO) nanoprobes, when conjugated with antibodies, showed enhanced magnetic resonance imaging (MRI) sensitivity for the detection of cancer markers compared with probes currently available Also, we successfully visualized small tumors implanted in a mouse Such high-performance, nanotechnology-based molecular probes could enhance the ability to visualize other biological events critical to diagnostics and therapeutics
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