Journal Article10.1038/NM1467
Artificially engineered magnetic nanoparticles for ultra-sensitive molecular imaging.
Jae Hyun Lee,Yong Min Huh,Young-wook Jun,Jung Wook Seo,Jung Tak Jang,Ho Taek Song,Sungjun Kim,Eun Jin Cho,Ho-Geun Yoon,Jin Suck Suh,Jinwoo Cheon +10 more
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TL;DR: These magnetism-engineered iron oxide (MEIO) nanoprobes, when conjugated with antibodies, showed enhanced magnetic resonance imaging (MRI) sensitivity for the detection of cancer markers compared with probes currently available and could enhance the ability to visualize other biological events critical to diagnostics and therapeutics.
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Abstract: Successful development of ultra-sensitive molecular imaging nanoprobes for the detection of targeted biological objects is a challenging task Although magnetic nanoprobes have the potential to perform such a role, the results from probes that are currently available have been far from optimal Here we used artificial engineering approaches to develop innovative magnetic nanoprobes, through a process that involved the systematic evaluation of the magnetic spin, size and type of spinel metal ferrites These magnetism-engineered iron oxide (MEIO) nanoprobes, when conjugated with antibodies, showed enhanced magnetic resonance imaging (MRI) sensitivity for the detection of cancer markers compared with probes currently available Also, we successfully visualized small tumors implanted in a mouse Such high-performance, nanotechnology-based molecular probes could enhance the ability to visualize other biological events critical to diagnostics and therapeutics
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Citations
•Journal Article
Photochemical design of stimuli-responsive nanoparticles prepared by supramolecular host–guest chemistry
Astrid F. Hirschbiel,Bernhard V. K. J. Schmidt,Peter Krolla-Sidenstein,James P. Blinco,Christopher Barner-Kowollik,Christopher Barner-Kowollik +5 more
TL;DR: In this paper, a thermoresponsive nanoparticle via sacrificial micelle formation based on supramolecular host-guest chemistry was introduced, where the authors employed reversible addition-fragmentation chain transfer (RAFT) polymerization to synthesize well-defined polymer blocks of poly(N,N-dimethylacrylamide) (poly(DMAAm)) (Mn,SEC = 10,700 g mol-1, Đ = 1.3) and poly(NiPAAm), carrying supramerolecular recognition units at the
32
Cobalt oxide nanoparticles induced oxidative stress linked to activation of TNF-α/caspase-8/p38-MAPK signaling in human leukemia cells.
Sourav Chattopadhyay,Sandeep Kumar Dash,Satyajit Tripathy,Balaram Das,Santanu Kar Mahapatra,Panchanan Pramanik,Somenath Roy +6 more
TL;DR: The results showed that CoO NPs induced oxidative stress and activated the signaling pathway of TNF‐α‐Caspase‐8‐p38‐Casingase‐3 to cancer cells and elicited a significant amount of ROS in cancer cells.
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The effect of mechanical properties of iron oxide nanoparticle-loaded functional nano-carrier on tumor targeting and imaging
TL;DR: The present result suggests that the mechanical properties (strength/flexibility) of nano-systems are also important factors to be controlled for targeted delivery and imaging.
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Nanomechanical characterization of chemical interaction between gold nanoparticles and chemical functional groups
Gyudo Lee,Hyungbeen Lee,Kihwan Nam,Jae-Hee Han,Jaemoon Yang,Sang Woo Lee,Dae Sung Yoon,Kilho Eom,Taeyun Kwon +8 more
TL;DR: This study sheds light on the experiment-based quantitative characterization of the binding affinity between nanomaterial and chemical groups, which will eventually provide an insight into how to effectively design the functional material using chemical groups.
MRI enhancement and tumor targeted drug delivery using Zn2+-doped Fe3O4 core/mesoporous silica shell nanocomposites
Weijun Fang,Wenjuan Zhu,Hu Chen,Hanyuan Zhang,Shi Hong,Wen-mei Wei,Tingting Zhao +6 more
- 30 Jan 2020
TL;DR: In such core–shell structured DOX/MNPs-FA nanocomposite, the high magnetism of iron oxide core can be tuned and achieved by controlling the Zn2+ dopant amount, making them suitable as excellent contrasts in T2-weighted MR imaging.
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