Journal Article10.1038/NM1467
Artificially engineered magnetic nanoparticles for ultra-sensitive molecular imaging.
Jae Hyun Lee,Yong Min Huh,Young-wook Jun,Jung Wook Seo,Jung Tak Jang,Ho Taek Song,Sungjun Kim,Eun Jin Cho,Ho-Geun Yoon,Jin Suck Suh,Jinwoo Cheon +10 more
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TL;DR: These magnetism-engineered iron oxide (MEIO) nanoprobes, when conjugated with antibodies, showed enhanced magnetic resonance imaging (MRI) sensitivity for the detection of cancer markers compared with probes currently available and could enhance the ability to visualize other biological events critical to diagnostics and therapeutics.
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Abstract: Successful development of ultra-sensitive molecular imaging nanoprobes for the detection of targeted biological objects is a challenging task Although magnetic nanoprobes have the potential to perform such a role, the results from probes that are currently available have been far from optimal Here we used artificial engineering approaches to develop innovative magnetic nanoprobes, through a process that involved the systematic evaluation of the magnetic spin, size and type of spinel metal ferrites These magnetism-engineered iron oxide (MEIO) nanoprobes, when conjugated with antibodies, showed enhanced magnetic resonance imaging (MRI) sensitivity for the detection of cancer markers compared with probes currently available Also, we successfully visualized small tumors implanted in a mouse Such high-performance, nanotechnology-based molecular probes could enhance the ability to visualize other biological events critical to diagnostics and therapeutics
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Citations
Molecular magnetic resonance contrast agents for the detection of cancer: past and present
TL;DR: The use of exogenously administered contrast agents allows compartment-specific enhancement of tumors, enabling imaging of functional blood and interstitial volumes and major trends in the development of specific probes for high-resolution imaging in molecular oncology are illustrated.
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Synthesis, characterization, and evaluation of PEGylated first-row transition metal ferrite nanoparticles as T2 contrast agents for high-field MRI
Abhinandan Banerjee,Barbara Blasiak,Barbara Blasiak,Eva Pasquier,Eva Pasquier,Boguslaw Tomanek,Boguslaw Tomanek,Boguslaw Tomanek,Simon Trudel +8 more
TL;DR: In this paper, poly(ethylene glycol) (PEG)-coated transition metal ferrite (MFe2O4) nanoparticles were generated by a one-pot synthetic protocol and found to be small, fairly monodisperse, and superparamagnetic in nature.
Hyaluronic acid-modified manganese-chelated dendrimer-entrapped gold nanoparticles for the targeted CT/MR dual-mode imaging of hepatocellular carcinoma
Ruizhi Wang,Yu Luo,Shuohui Yang,Jiang Lin,Dongmei Gao,Yan Zhao,Jinguo Liu,Xiangyang Shi,Xiaolin Wang +8 more
TL;DR: A novel strategy for preparing multifunctional NPs via dendrimer nanotechnology is introduced, used to image HCC cells in vitro and orthotopically transplanted HCC tumors in a unique in vivo model through the CD44 receptor-mediated endocytosis pathway.
Versatile theranostics agents designed by coating ferrite nanoparticles with biocompatible polymers.
Maryam Zahraei,Marzia Marciello,Ana Lazaro-Carrillo,Angeles Villanueva,Angeles Villanueva,Fernando Herranz,Marina Talelli,Rocío Costo,Ahmad Monshi,Daryoush Shahbazi-Gahrouei,Mehdi Amirnasr,Behshid Behdadfar,M. P. Morales +12 more
TL;DR: Three biocompatible polymers, PEG, dextran and chitosan, have been used in this work to control the colloidal stability of magnetic nanoparticles and to vary the aggregation state in order to study their effect on relaxometric and heating properties.
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Magnetic Nanotweezers for Interrogating Biological Processes in Space and Time.
TL;DR: Recent developments in magnetic nanotweezers (MNTs) are presented as a useful tool for interrogating the spatiotemporal control of cells in living tissue and the utility of MNTs for manipulating biological functions and activities with various spatial and temporal resolution.
47
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