Journal Article10.1007/S10571-019-00656-W
Artemisia amygdalina Upregulates Nrf2 and Protects Neurons Against Oxidative Stress in Alzheimer Disease
Nasreena Sajjad,Abubakar Wani,Ankita Sharma,Rohaya Ali,Sumaya Hassan,Rabia Hamid,Huma Habib,Bashir A. Ganai +7 more
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TL;DR: It is demonstrated that Artemisia amygdalina protects neurons through upregulation of Nrf2 pathway, an emerging regulator of cellular resistance to oxidants, and may have the possibility to be a therapeutic agent for Alzheimer disease.
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Abstract: Alzheimer disease is a complex neurodegenerative disorder. It is the common form of dementia in elderly people. The etiology of this disease is multifactorial, pathologically it is accompanied with accumulation of amyloid beta and neurofibrillary tangles. Accumulation of amyloid beta and mitochondrial dysfunction leads to oxidative stress. In this study, neuroprotective effect of Artemisiaamygdalina against H2O2-induced death was studied in differentiated N2a and SH-SY5Ycells. Cells were treated with H2O2 to induce toxicity which was attenuated by Artemisia amygdalina. The nuclear factor erythroid 2-related factor 2 (Nrf2) is an emerging regulator of cellular resistance to oxidants. It controls the basal and induced expression of antioxidant response element-dependent genes. Further, we demonstrated that Artemisia amygdalina protects neurons through upregulation of Nrf2 pathway. Moreover, reactive oxygen species and mitochondrial membrane potential loss formed by H2O2 was attenuated by Artemisia amygdalina. Thus, Artemisia amygdalina may have the possibility to be a therapeutic agent for Alzheimer disease.
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Citations
Oxidative Stress-Mediated Blood-Brain Barrier (BBB) Disruption in Neurological Diseases
Ke Song,Yuanyuan Li,Hanlai Zhang,Na An,Na An,Yufei Wei,Liqin Wang,Chao Tian,Mengchen Yuan,Yikun Sun,Yanwei Xing,Yonghong Gao +11 more
TL;DR: The role of oxidative stress-mediated BBB disruption in neurological diseases, such as hemorrhagic stroke, ischemic stroke (IS), Alzheimer's disease (AD), Parkinson’s disease (PD), traumatic brain injury (TBI), amyotrophic lateral sclerosis (ALS), and cerebral small vessel disease (CSVD), is discussed.
Antiviral and Immunomodulation Effects of Artemisia
TL;DR: Artemisia is one of the most widely distributed genera of the family Astraceae with more than 500 diverse species growing mainly in the temperate zones of Europe, Asia and North America as mentioned in this paper.
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Natural antioxidants for neuroinflammatory disorders and possible involvement of Nrf2 pathway: A review.
TL;DR: The role of Nrf2 in cellular redox and metabolic system is discussed in this paper, where the authors evaluate the neuroprotective property of natural substance against neuroinflammatory disorders by reviewing the studies done till today.
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Berberine ameliorates iron levels and ferroptosis in the brain of 3 × Tg-AD mice
TL;DR: For the first time, these results showed that BBR could inhibit iron levels and ferroptosis in the brains of 3 × Tg-AD model mice and partially protect against RSL3-induced ferroPTosis via the activation of Nrf2 signaling.
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Phytochemicals Targeting Oxidative Stress, Interconnected Neuroinflammatory, and Neuroapoptotic Pathways Following Radiation
01 May 2022
TL;DR: In this paper , the destructive effects of radiation on the induction of neurodegenerative diseases by dysregulating oxidative stress, apoptosis, and inflammation are discussed, and the promising effects of polyphenols and other candidate phytochemicals in preventing and treating radiation-induced neuro degenerative disorders are also described.
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