Journal Article10.1016/J.IJANTIMICAG.2006.11.011
Arrhythmias associated with fluoroquinolone therapy.
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TL;DR: Moxifloxacin carries the greatest risk of QT prolongation from all available quinolones in clinical practice and it should be used with caution in patients with predisposing factors for Torsades de pointes (Tdp).
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About: This article is published in International Journal of Antimicrobial Agents. The article was published on 01 Apr 2007. The article focuses on the topics: QT interval & Torsades de pointes.
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Citations
Lack of electrocardiographic effect of dexlansoprazole MR, a novel modified-release formulation of the proton pump inhibitor dexlansoprazole, in healthy participants.
TL;DR: Pharmacokinetic analysis indicated that QT intervals were measured at the time of maximum drug plasma concentration, and neither dexlansoprazole MR 90 mg nor 300 mg prolonged QTcF intervals in healthy participants.
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Oral fluoroquinolones and risk of glaucoma.
TL;DR: There was no detected increased association of the development of glaucoma with current, recent, or past use of systemic fluoroquinolone but a minimal statistically significant increased risk was associated with distant use.
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Cardiac Troponin-I (cTnI) a Biomarker of Cardiac Injuries Induced by Doxorubicin Alone and in Combination with Ciprofloxacin, Following Acute and Chronic Dose Protocol in Sprague Dawley Rats
Exercise-induced acute renal failure in a trainee cyclist without hypouricemia: Successful athletic career post-treatment.
TL;DR: His serum uric acid levels were rather high, at 6.4 mg/dL, and he is the first patient with ALPE to succeed as a professional athlete in an anaerobic sport.
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Ciprofloxacin in critically ill children.
G Sideri,Dimitris A. Kafetzis,Evridiki K. Vouloumanou,Evridiki K. Vouloumanou,J Papadatos,J Papadatos,M Papadimitriou,M Papadimitriou,Matthew E. Falagas,Matthew E. Falagas +9 more
TL;DR: It is suggested that ciprofloxacin may be a useful option for critically ill children without cystic fibrosis, and useful information is provided regarding short-term adverse events associated with ciproprofl oxacin.
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References
A Critical Review of the Fluoroquinolones
George G. Zhanel,George G. Zhanel,Kelly Ennis,Lavern M. Vercaigne,Andrew Walkty,Alfred S. Gin,John M. Embil,John M. Embil,Heather J. Smith,Daryl J. Hoban,Daryl J. Hoban +10 more
TL;DR: The new fluoroquinolones offer several advantages over ciprofloxacin and are emerging as important therapeutic agents in the treatment of community-acquired respiratory infections, and may be used orally in place of intravenous antibacterials.
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Torsade de pointes due to noncardiac drugs: most patients have easily identifiable risk factors.
TL;DR: It is suggested that almost all patients with torsade de pointes secondary to noncardiac drugs have risk factors that can be easily identified from the medical history before the initiation of therapy with the culprit drug.
302
Rates of Torsades de Pointes Associated with Ciprofloxacin, Ofloxacin, Levofloxacin, Gatifloxacin, and Moxifloxacin
TL;DR: To compare the rates of torsades de pointes associated with ciprofloxacin, ofloxacIn, levofloxACin, gatifloxAcin, and moxiflOxacin administration, the levels of these drugs in clinical practice and in animal studies are compared.
203
Prescription of QT-prolonging drugs in a cohort of about 5 million outpatients.
Lesley H. Curtis,Truls Østbye,Veronica Sendersky,Steve Hutchison,Nancy M. Allen LaPointe,Sana M. Al-Khatib,Sally Usdin Yasuda,Peter E. Dans,Alan Wright,Robert M. Califf,Raymond L. Woosley,Kevin A. Schulman +11 more
TL;DR: Using the administrative claims database of a national pharmaceutical benefit manager, a retrospective cohort study in 4,825,345 subjects aged 18 years or older found concurrent prescription of QT-prolonging drugs is common in the outpatient setting, and antidepressants are involved in half of these cases.
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