Arrhythmias associated with fluoroquinolone therapy.

TL;DR: Compound 2a showed excellent in vivo activity against the experimental murine pneumonia model due to multidrug resistant Streptococcus pneumoniae (MDRSP) and favorable profiles in preliminary toxicological and nonclinical pharmacokinetic studies.

TL;DR: In this paper, the relationship between different quinolone structures and toxicity in zebrafish embryos using in-vivo and in-silico methods was investigated using quantitative structure-toxicity relationship (QSTR) modeling.

TL;DR: A triple therapy with 800 mg of moxifloxacin a day for 10 days is more effective than the same treatment for 5 or 7 days and a treatment with 400mg of mxiflOxacinA day for10 days for the first-line eradication of H. pylori infection.

TL;DR: In this article, the frequency, onset, frequency of medications, and risk factors for the acquired long QT syndrome in intensive care patients were determined in a retrospective chart review of 88 subjects, hourly corrected QT intervals calculated using the Bazett formula were collected.

TL;DR: It is suggested that almost all patients with torsade de pointes secondary to noncardiac drugs have risk factors that can be easily identified from the medical history before the initiation of therapy with the culprit drug.

TL;DR: To compare the rates of torsades de pointes associated with ciprofloxacin, ofloxacIn, levofloxACin, gatifloxAcin, and moxiflOxacin administration, the levels of these drugs in clinical practice and in animal studies are compared.

TL;DR: Using the administrative claims database of a national pharmaceutical benefit manager, a retrospective cohort study in 4,825,345 subjects aged 18 years or older found concurrent prescription of QT-prolonging drugs is common in the outpatient setting, and antidepressants are involved in half of these cases.