Are aortic aneurysms caused by atherosclerosis
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TL;DR: It appears that the risk factors for aortic Atherosclerosis and probably atherosclerosis itself are necessary elements in the causal pathway for the great majority of aorti aneurysms in this cohort of men of Japanese ancestry in Hawaii.
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Abstract: BACKGROUNDThe emerging controversy concerning the causal role of atherosclerosis in the development of aortic aneurysms was examined using the accumulated clinical and autopsy data obtained during a 20-year follow-up of a cohort of more than 8,000 men of Japanese ancestry in Hawaii.METHODS AND RESULTSAnalyses of 174 clinical incident events indicated that there were two types of aneurysmal disease, 151 aortic aneurysms and 23 aortic dissections. The baseline risk factors that predicted the clinical aortic aneurysms were the same factors that predicted aortic atherosclerosis in the same cohort, namely, high blood pressure, high serum cholesterol, and cigarette smoking. These same risk factors were also significantly associated with the occurrence of 27 aortic aneurysms among 293 autopsied men. The less common aortic dissections had an age-specific incidence pattern indicative of an innate susceptibility precipitated by an exposure to another factor. This pattern was consistent with the findings that the in...
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Citations
Influence of wall shear stress and geometry on the lumen surface concentration of low density lipoprotein in a model abdominal aortic aneurysm
TL;DR: The correlation between the wall shear stress (WSS) and the surface concentration variation of low density lipoprotein (LDL) on the walls of an idealized abdominal aortic aneurysm (AAA) is explored and the correlation is found to be linked to the local fluid-flow pattern.
Orchidectomy, but not ovariectomy, regulates angiotensin II-induced vascular diseases in apolipoprotein E-deficient mice.
TL;DR: The results suggest that estrogen does not mediate gender differences in AngII-induced AAA, through mechanisms that do not appear to involve circulating renin or angiotensin receptor density.
Mechanisms of abdominal aortic aneurysm formation
Alan Daugherty,Lisa A. Cassis +1 more
TL;DR: Definition of specific mechanisms would identify target sites for potential pharmacologic intervention and markedly improve the medical treatment and prognosis of AAA.
Traditional and novel risk factors for clinically diagnosed abdominal aortic aneurysm: the Kaiser multiphasic health checkup cohort study.
TL;DR: It is suggested that elevated white blood cell count and reduced kidney function may improve risk stratification for clinically relevant AAA and confirm that major atherosclerotic risk factors, except for diabetes and obesity, are also prospectively related to AAA.
Associations of Diabetes and Obesity with Risk of Abdominal Aortic Aneurysm in Men.
Lu Wang,Luc Djoussé,Yiqing Song,Akintunde O. Akinkuolie,Chisa Matsumoto,JoAnn E. Manson,J. Michael Gaziano,Howard D. Sesso +7 more
TL;DR: In a large cohort of middle-aged and older men, obesity was associated with a higher risk of abdominal aortic aneurysm, while history of diabetes tended to associate with a lower risk of diagnosed AAA, particularly over longer follow-up.
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Elastolytic and Collagenolytic Studies of Arteries: Implications for the Mechanical Properties of Aneurysms
TL;DR: It is concluded that wall integrity depends on intact collagen rather than elastin, and the latter vessels exhibited dramatically greater dilatation and compliance changes after treatment with collagenase, corresponding to the greater tendency of aneurysms to develop in internal and common iliac arteries.
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Changing incidence of abdominal aortic aneurysms: a population-based study
L. Joseph Melton,Bickerstaff Lk,Larry H. Hollier,Hubert J. Van Peenen,J.T. Lie,Peter C. Pairolero,Kenneth J. Cherry,W. Michael O'Fallon +7 more
TL;DR: While all clinical classes of abdominal aortic aneurysms became more frequent, the greatest rise in incidence was for small, asymptomatic, and uncomplicated aneurYSms which suggested an important role for more complete case ascertainment in recent years.
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Familial Tendency for Abdominal Aortic Aneurysms
Kaj Johansen,Thomas D. Koepsell +1 more
TL;DR: It is suggested that the relatives of patients with AAA may themselves be at significantly increased risk for the development of aneurysmal degeneration, and noninvasive screening to detect early AAA formation may be warranted in relatives.
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A mutation in the gene for type III procollagen (COL3A1) in a family with aortic aneurysms.
TL;DR: Results demonstrated that mutations in the type III procollagen gene can cause familial aortic aneurysms and that DNA tests for such mutations can identify individuals at risk for aneurYSms.
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