Are aortic aneurysms caused by atherosclerosis
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TL;DR: It appears that the risk factors for aortic Atherosclerosis and probably atherosclerosis itself are necessary elements in the causal pathway for the great majority of aorti aneurysms in this cohort of men of Japanese ancestry in Hawaii.
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Abstract: BACKGROUNDThe emerging controversy concerning the causal role of atherosclerosis in the development of aortic aneurysms was examined using the accumulated clinical and autopsy data obtained during a 20-year follow-up of a cohort of more than 8,000 men of Japanese ancestry in Hawaii.METHODS AND RESULTSAnalyses of 174 clinical incident events indicated that there were two types of aneurysmal disease, 151 aortic aneurysms and 23 aortic dissections. The baseline risk factors that predicted the clinical aortic aneurysms were the same factors that predicted aortic atherosclerosis in the same cohort, namely, high blood pressure, high serum cholesterol, and cigarette smoking. These same risk factors were also significantly associated with the occurrence of 27 aortic aneurysms among 293 autopsied men. The less common aortic dissections had an age-specific incidence pattern indicative of an innate susceptibility precipitated by an exposure to another factor. This pattern was consistent with the findings that the in...
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Pathophysiology of Acute Aortic Syndromes
Christoph A. Nienaber
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TL;DR: This chapter reviews the etiology of aortic wall disease, natural history, and the pathophysiology of the complexity of acuteAortic syndromes.
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Dissecting aneurysms involving both anterior cerebral artery and aorta.
TL;DR: Coexistence of dissecting aneurysms in the anterior cerebral artery and aorta suggests the presence of underlying pathogenesis that is common to these two dissection processes.
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Thoracic Aortic Disease
Bulat A. Ziganshin,Bulat A. Ziganshin,John A. Elefteriades +2 more
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TL;DR: This chapter discusses the current understanding of the pathophysiology of thoracic aortic diseases, the current diagnostic approaches, and up-to-date management strategies based on recent guidelines and published literature.
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Prevalence of Obstructive Sleep Apnea in Patients with Thoracic Aortic Aneurysm: A Prospective, Parallel Cohort Study
Thomas Gaisl,Patrick Baumgartner,Protazy Rejmer,Martin Osswald,Maurice Roeder,Sira Thiel,Simon F. Stämpfli,Christian F. Clarenbach,Felix C. Tanner,Malcolm Kohler +9 more
TL;DR: Patients with TAA have a higher prevalence of OSA when compared to the general population, and since OSA is effectively treatable and might contribute to the pathogenesis of TAA, further longitudinal trials are needed to assess the association.
Characterization of aneurysmal aortas by biochemical, thermal, and dielectric techniques.
Valérie Samouillan,Jany Dandurand,Colette Lacabanne,Andrea Stella,Mauro Gargiulo,Annamaria Degani,Alessandro Gandaglia,Michel Spina +7 more
TL;DR: The chain dynamics of AAA tissues are investigated by two techniques generally used for the characterization of polymers, Differential scanning calorimetry (DSC) and thermally stimulated currents (TSC), and the obtained data are correlated with biochemical analyses.
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TL;DR: It is suggested that the relatives of patients with AAA may themselves be at significantly increased risk for the development of aneurysmal degeneration, and noninvasive screening to detect early AAA formation may be warranted in relatives.
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