Are aortic aneurysms caused by atherosclerosis
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TL;DR: It appears that the risk factors for aortic Atherosclerosis and probably atherosclerosis itself are necessary elements in the causal pathway for the great majority of aorti aneurysms in this cohort of men of Japanese ancestry in Hawaii.
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Abstract: BACKGROUNDThe emerging controversy concerning the causal role of atherosclerosis in the development of aortic aneurysms was examined using the accumulated clinical and autopsy data obtained during a 20-year follow-up of a cohort of more than 8,000 men of Japanese ancestry in Hawaii.METHODS AND RESULTSAnalyses of 174 clinical incident events indicated that there were two types of aneurysmal disease, 151 aortic aneurysms and 23 aortic dissections. The baseline risk factors that predicted the clinical aortic aneurysms were the same factors that predicted aortic atherosclerosis in the same cohort, namely, high blood pressure, high serum cholesterol, and cigarette smoking. These same risk factors were also significantly associated with the occurrence of 27 aortic aneurysms among 293 autopsied men. The less common aortic dissections had an age-specific incidence pattern indicative of an innate susceptibility precipitated by an exposure to another factor. This pattern was consistent with the findings that the in...
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Citations
CT and MRI of Acute Thoracic Cardiovascular Emergencies
Aamer Chughtai,Ella A. Kazerooni +1 more
TL;DR: The three most common life-threatening cardiovascular processes in which advanced imaging plays a role, particularly CT, are discussed, including pulmonary embolism, aortic dissection, and coronary artery disease.
20
Extracellular Matrix Defects in Aneurysmal Fibulin-4 Mice Predispose to Lung Emphysema
Natasja W. M. Ramnath,Koen M. van de Luijtgaarden,Ingrid van der Pluijm,Menno van Nimwegen,Paula M. van Heijningen,Sigrid M. A. Swagemakers,Bibi S. van Thiel,Ruziedi Y. Ridwan,Nicole van Vliet,Marcel Vermeij,Luuk J. A. C. Hawinkels,Anne de Munck,Oleh Dzyubachyk,Erik Meijering,Peter J. van der Spek,Robbert J. Rottier,Hiromi Yanagisawa,Rudi W. Hendriks,Roland Kanaar,Ellen V. Rouwet,Alex KleinJan,Jeroen Essers +21 more
TL;DR: It is shown that COPD is significantly more prevalent in aneurysm patients compared to arterial occlusive disease patients, independent of smoking, other clinical risk factors and inflammation.
Human abdominal aortic aneurysm (AAA): Evidence for an autoimmune antigen-driven disease.
Song Lu,John White,Ifeyinwa Nwaneshiudu,Adaobi I. Nwaneshiudu,Dimitri S. Monos,Charalambos C. Solomides,Emilia L. Oleszak,Chris D. Platsoucas +7 more
TL;DR: Abdominal aortic aneurism (AAA) is a complex immunological disease with a strong genetic component, and one of the ten leading causes of death of individuals 55-74 years old worldwide as mentioned in this paper .
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Descending Thoracic Aortic Dissection: Evaluation and Management in the Era of Endovascular Technology
TL;DR: Recent advances of endovascular technology have broadened the potential application of this catheter-based therapy in aortic pathologies, including descending thoracic aorta dissection, and the etiology, pathogenesis, and classification of this condition are discussed.
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Aortic plaque imaging and monitoring atherosclerotic plaque interventions.
Yukihiko Momiyama,Zahi A. Fayad +1 more
TL;DR: Plaques in the thoracic and abdominal aortas were found to be characteristically associated with hypercholesterolemia and smoking, respectively, suggesting different susceptibilities to risk factors, and MRI is a powerful tool to serially evaluate plaque progression and regression.
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Bias in analytic research
TL;DR: This chapter focuses on the bias in analytic research, which is a general trend toward fewer study subjects but more study authors was also noted.
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Elastolytic and Collagenolytic Studies of Arteries: Implications for the Mechanical Properties of Aneurysms
TL;DR: It is concluded that wall integrity depends on intact collagen rather than elastin, and the latter vessels exhibited dramatically greater dilatation and compliance changes after treatment with collagenase, corresponding to the greater tendency of aneurysms to develop in internal and common iliac arteries.
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Changing incidence of abdominal aortic aneurysms: a population-based study
L. Joseph Melton,Bickerstaff Lk,Larry H. Hollier,Hubert J. Van Peenen,J.T. Lie,Peter C. Pairolero,Kenneth J. Cherry,W. Michael O'Fallon +7 more
TL;DR: While all clinical classes of abdominal aortic aneurysms became more frequent, the greatest rise in incidence was for small, asymptomatic, and uncomplicated aneurYSms which suggested an important role for more complete case ascertainment in recent years.
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Familial Tendency for Abdominal Aortic Aneurysms
Kaj Johansen,Thomas D. Koepsell +1 more
TL;DR: It is suggested that the relatives of patients with AAA may themselves be at significantly increased risk for the development of aneurysmal degeneration, and noninvasive screening to detect early AAA formation may be warranted in relatives.
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A mutation in the gene for type III procollagen (COL3A1) in a family with aortic aneurysms.
TL;DR: Results demonstrated that mutations in the type III procollagen gene can cause familial aortic aneurysms and that DNA tests for such mutations can identify individuals at risk for aneurYSms.
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