Are aortic aneurysms caused by atherosclerosis
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TL;DR: It appears that the risk factors for aortic Atherosclerosis and probably atherosclerosis itself are necessary elements in the causal pathway for the great majority of aorti aneurysms in this cohort of men of Japanese ancestry in Hawaii.
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Abstract: BACKGROUNDThe emerging controversy concerning the causal role of atherosclerosis in the development of aortic aneurysms was examined using the accumulated clinical and autopsy data obtained during a 20-year follow-up of a cohort of more than 8,000 men of Japanese ancestry in Hawaii.METHODS AND RESULTSAnalyses of 174 clinical incident events indicated that there were two types of aneurysmal disease, 151 aortic aneurysms and 23 aortic dissections. The baseline risk factors that predicted the clinical aortic aneurysms were the same factors that predicted aortic atherosclerosis in the same cohort, namely, high blood pressure, high serum cholesterol, and cigarette smoking. These same risk factors were also significantly associated with the occurrence of 27 aortic aneurysms among 293 autopsied men. The less common aortic dissections had an age-specific incidence pattern indicative of an innate susceptibility precipitated by an exposure to another factor. This pattern was consistent with the findings that the in...
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Citations
Dilation and reduced distensibility of carotid artery in patients with abdominal aortic aneurysms.
Shinji Makita,Atsushi Ohira,Rintarou Tachieda,Shigehiro Itoh,Yoshiteru Moriai,Hiroyuki Niinuma,Motoyuki Nakamura,Katsuhiko Hiramori +7 more
TL;DR: Excessive arterial dilation and reduced distensibility without severe intimal disease were found in the carotid arteries of patients with AAA, suggesting that these patients may be subject to systemic arterial alterations, including structural and functional abnormalities.
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α-Tocopherol (vitamin E) and β-carotene supplementation does not affect the risk for large abdominal aortic aneurysm in a controlled trial
TL;DR: Long-term supplementation with α-tocopherol or β-carotene had no preventive effect on large abdominal aortic aneurysm among male smokers, and neither antioxidant affected risk for ruptured AAA.
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Aortic Dissection and Other Acute Aortic Syndromes: Diagnostic Imaging Findings from Acute to Chronic Longitudinal Progression.
TL;DR: In acute aortic syndromes, most critical findings affecting initial management and prognosis are obtained at CT and can be systematically identified using the DISSECTION mnemonic algorithm at any s...
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Increasing incidence of aneurysms of the abdominal aorta in The Netherlands.
J.B. Reitsma,H.J.C.M. Pleumeekers,H.J.C.M. Pleumeekers,A.W. Hoes,A.W. Hoes,J. Kleijnen,J. Kleijnen,R.M. de Groot,Michael J. Jacobs,Michael J. Jacobs,Diederick E. Grobbee,Diederick E. Grobbee,Jan G.P. Tijssen,Jan G.P. Tijssen +13 more
TL;DR: There was an impressive increase in the hospital based incidence for aneurysms of the abdominal aorta during the past two decades in The Netherlands, but gender differences and the rise in the number of ruptured aneurYSms suggest that a real increase in incidence may exist, especially in men.
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Effect of bezafibrate therapy on atherosclerotic aortic plaques detected by MRI in dyslipidemic patients with hypertriglyceridemia.
Makoto Ayaori,Yukihiko Momiyama,Zahi A. Fayad,Atsushi Yonemura,Reiko Ohmori,Teruyoshi Kihara,Nobukiyo Tanaka,Kazuhiro Nakaya,Masatsune Ogura,Shojiro Sawada,Hiroaki Taniguchi,Masatoshi Kusuhara,Masayoshi Nagata,Haruo Nakamura,Fumitaka Ohsuzu +14 more
TL;DR: Bezafibrate induced plaque regression in thoracic and abdominal aortas with marked TG reduction and HDL-cholesterol increase, but the processes of plaque regression and vascular remodeling may differ between thoraci and abdominalAortas.
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Elastolytic and Collagenolytic Studies of Arteries: Implications for the Mechanical Properties of Aneurysms
TL;DR: It is concluded that wall integrity depends on intact collagen rather than elastin, and the latter vessels exhibited dramatically greater dilatation and compliance changes after treatment with collagenase, corresponding to the greater tendency of aneurysms to develop in internal and common iliac arteries.
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Changing incidence of abdominal aortic aneurysms: a population-based study
L. Joseph Melton,Bickerstaff Lk,Larry H. Hollier,Hubert J. Van Peenen,J.T. Lie,Peter C. Pairolero,Kenneth J. Cherry,W. Michael O'Fallon +7 more
TL;DR: While all clinical classes of abdominal aortic aneurysms became more frequent, the greatest rise in incidence was for small, asymptomatic, and uncomplicated aneurYSms which suggested an important role for more complete case ascertainment in recent years.
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Familial Tendency for Abdominal Aortic Aneurysms
Kaj Johansen,Thomas D. Koepsell +1 more
TL;DR: It is suggested that the relatives of patients with AAA may themselves be at significantly increased risk for the development of aneurysmal degeneration, and noninvasive screening to detect early AAA formation may be warranted in relatives.
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A mutation in the gene for type III procollagen (COL3A1) in a family with aortic aneurysms.
TL;DR: Results demonstrated that mutations in the type III procollagen gene can cause familial aortic aneurysms and that DNA tests for such mutations can identify individuals at risk for aneurYSms.
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