APRIL promotes B-1 cell-associated neoplasm
Lourdes Planelles,Lourdes Planelles,Carla E. Carvalho-Pinto,Carla E. Carvalho-Pinto,Gijs Hardenberg,Salette Smaniotto,Wilson Savino,Ruth Gómez-Caro,Melchor Alvarez-Mon,Joan de Jong,Eric Eldering,Carlos Martínez-A,Jan Paul Medema,Michael Hahne,Michael Hahne +14 more
TL;DR: It is described that 9- to 12-month-old APRIL transgenic mice develop lymphoid tumors that originate from expansion of the peritoneal B-1 B cell population, suggesting that APRIL antagonism may provide a therapeutic strategy to treat B-CLL patients.
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About: This article is published in Cancer Cell. The article was published on 01 Oct 2004. and is currently open access. The article focuses on the topics: Mesenteric lymph nodes & B-1 cell.
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Citations
Immunosuppressive Mechanisms of Regulatory B Cells.
Diego Catalán,Miguel Andrés Mansilla,Ashley Ferrier,Lilian Soto,Kristine Oleinika,Juan Carlos Aguillón,Octavio Aravena +6 more
TL;DR: The role of regulatory B cells in restraining the pathology associated with exacerbated inflammatory responses in autoimmunity and graft rejection has been consistently demonstrated, while more recent studies have suggested a role for this population in other immune-related conditions, such as infections, allergy, cancer, and chronic metabolic diseases as mentioned in this paper.
On the cytokines produced by human neutrophils in tumors.
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Neutrophil-derived APRIL concentrated in tumor lesions by proteoglycans correlates with human B-cell lymphoma aggressiveness
Juerg Schwaller,Pascal Schneider,Paulette Mhawech-Fauceglia,Thomas Alexander Mckee,Samir Myit,Thomas Matthes,Jurg Tschopp,Olivier Donzé,Frédérique-Anne Le Gal,Bertrand Huard +9 more
TL;DR: A retrospective clinical analysis revealed a significant correlation between high expression of APRIL in tumor lesions and decreased overall patient survival rate, indicating that APRIL produced by inflammatory cells infiltrating lymphoma lesions may increase tumor aggressiveness and affect disease outcome.
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Tcl1 functions as a transcriptional regulator and is directly involved in the pathogenesis of CLL
Yuri Pekarsky,Alexey Palamarchuk,Vadim Maximov,Alexey Efanov,Natalya Nazaryan,Urmila Santanam,Laura Z. Rassenti,Thomas J. Kipps,Carlo M. Croce +8 more
TL;DR: The results indicate that Tcl1 overexpression causes B-CLL by directly enhancing NF-κB activity and inhibiting AP-1.
137
Gene expression profiles associated with treatment response in oligodendrogliomas
Pim J. French,Sigrid M. A. Swagemakers,Jord H. A. Nagel,Mathilde C.M. Kouwenhoven,Eric Brouwer,Peter J. van der Spek,Theo M. Luider,Johan M. Kros,Martin J. van den Bent,Peter A. E. Sillevis Smitt +9 more
TL;DR: This study is the first to correlate gene expression with chromosomal aberrations and clinical performance (response to treatment and survival) in oligodendrogliomas and identify patient subgroups with good prognosis and those that will benefit from chemotherapeutic treatments.
120
References
DCs induce CD40-independent immunoglobulin class switching through BLyS and APRIL
Mikhail B. Litinskiy,Bernardetta Nardelli,David M. Hilbert,Bing He,András Schaffer,Paolo Casali,Andrea Cerutti +6 more
TL;DR: By eliciting CD40-independent Ig class switching and plasmacytoid differentiation, BLyS and APRIL critically link the innate and adaptive immune responses.
BAFF AND APRIL: a tutorial on B cell survival.
TL;DR: The BAFF system provides not only potential insight into the development of autoreactive B cells but a relatively simple paradigm to begin considering the balancing act between survival, growth, and death that affects all cells.
1K
APRIL, a New Ligand of the Tumor Necrosis Factor Family, Stimulates Tumor Cell Growth
Michael Hahne,Takao Kataoka,Michael Schröter,Kay Hofmann,Martin Irmler,Jean-Luc Bodmer,Pascal Schneider,Tierry Bornand,Nils Holler,Lars E. French,Bernard Sordat,Donata Rimoldi,Jürg Tschopp +12 more
TL;DR: A novel member of the TNF family designated APRIL (for a proliferation-inducing ligand) is described and it is suggested that APRIL may be implicated in the regulation of tumor cell growth.
631
Human chronic lymphocytic leukemia modeled in mouse by targeted TCL1 expression
TL;DR: Transgenic animals containing a nucleic acid sequence encoding TCL1 operably linked to transcriptional control sequences directing expression to B cells are described in this article, which provide a useful animal model system for human B cell chronic lymphocytic leukemia.
516
Impaired IgA class switching in APRIL-deficient mice.
Emanuela Castigli,Sumi Scott,Fatma Dedeoglu,Paul J. Bryce,Haifa H. Jabara,Atul K. Bhan,Emiko Mizoguchi,Raif S. Geha +7 more
TL;DR: Results suggest that APRIL down-regulates T cell-dependent antibody responses and promotes IgA class switching in CD40-deficient IgM(+)IgD(+) sorted B cells.
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