Journal Article10.1016/J.MIMET.2018.11.007
Applying simple linear combination, multiple logistic and factor analysis methods for candidate fecal bacteria as novel biomarkers for early detection of adenomatous polyps and colon cancer.
Sama Rezasoltani,Maryam Sharafkhah,Hamid Asadzadeh Aghdaei,Ehsan Nazemalhosseini Mojarad,Hossein Dabiri,Abbas Akhavan Sepahi,Mohammad Hossein Modarressi,Mohammad Mehdi Feizabadi,Mohammad Reza Zali +8 more
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TL;DR: It was found that a simple linear combination was an appropriate model for discriminating AP and CRC cases, compared to the NC, with a sensitivity of 91.4% and specificity of 93.5%.
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About: This article is published in Journal of Microbiological Methods. The article was published on 12 Nov 2018.
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Citations
Microbiome and colorectal cancer: Roles in carcinogenesis and clinical potential.
TL;DR: Current knowledge on the healthy microbiome of the gut and how it is altered in colorectal cancer and other related disease conditions is surveyed and a special focus on host-microbiome interaction mechanisms that may be important to explain how dysbiosis can lead to chronic inflammation and drive processes that influence carcinogenesis and tumor progression in colon cancer.
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Novel Diagnostic Biomarkers in Colorectal Cancer
TL;DR: Recent advances in novel diagnostic biomarkers for tumor tissue, blood and stool samples in CRC patients are discussed.
145
Biomarkers for detecting colorectal cancer non-invasively: DNA, RNA or proteins?
TL;DR: It can be concluded that, despite its deficiencies, the protein (haemoglobin) detection-based faecal immunochemical test (FIT) today presents the most cost-effective option for non-invasive CRC screening.
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Fusobacterium nucleatum in the Colorectum and Its Association with Cancer Risk and Survival: A Systematic Review and Meta-analysis
Christian Gethings-Behncke,Helen G. Coleman,Haydee W. T. Jordao,Daniel B. Longley,Nyree Crawford,Liam J. Murray,Andrew T. Kunzmann +6 more
TL;DR: A consistent increase in the prevalence and/or abundance of F. nucleatum in colorectal cancer tissue and fecal samples compared with controls was apparent and was associated with poorer overall survival.
The Role of Gut Barrier Dysfunction and Microbiome Dysbiosis in Colorectal Cancer Development.
TL;DR: In this article, the interactive roles of Gut-barrier dysfunction, microbiome dysbiosis, and exposure to endogenous toxins as another mechanism in colorectal cancer development, and how biomarkers of colonic mucosal barrier function may provide avenues for disease, prevention and detection.
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TL;DR: Inherited genetic factors make a minor contribution to susceptibility to most types of neoplasms, which indicates that the environment has the principal role in causing sporadic cancer.
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Global burden of cancers attributable to infections in 2008: a review and synthetic analysis
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TL;DR: Application of existing public health methods for infection prevention, such as vaccination, safer injection practice, or antimicrobial treatments, could have a substantial effect on the future burden of cancer worldwide.
Fusobacterium nucleatum infection is prevalent in human colorectal carcinoma
Mauro Castellarin,René L. Warren,J. Douglas Freeman,Lisa Dreolini,Martin Krzywinski,Jaclyn Strauss,Rebecca O Barnes,Peter H. Watson,Emma Allen-Vercoe,Richard A. Moore,Robert A. Holt +10 more
TL;DR: Overabundance of Fusobacterium sequences in tumor versus matched normal control tissue is verified by quantitative PCR analysis from a total of 99 subjects, and a positive association with lymph node metastasis is observed.
Colon Cancer Survival Rates With the New American Joint Committee on Cancer Sixth Edition Staging
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TL;DR: Reduction of butyrate-producing bacteria in the gut microbiota of CRC patients and increase of opportunistic pathogens may constitute a major structural imbalance of gut microbiota in CRC patients.
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