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Applied biopharmaceutics and pharmacokinetics
Leon Shargel,Susanna Wu-Pong,Andrew B.C. Yu +2 more
- 01 Jan 1980
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TL;DR: Applied biopharmaceutics & pharmacokinetics, Applied biophARMaceutics and pharmacokinetic research, کتابخانه دیجیتال شاپور اهواز
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Abstract: Mathematical fundamentals on pharmacokinetics introduction to biopharmaceutics and pharmacokinetics one compartment model physiological factors relating to drug absorption biopharmaceutic considerations in drug product design modified release drug products delivery of biotechnical products and targetted drug delivery systems pharmacokinetics of drug absorption bioavailability and bioequivalence multicompartmental models drug distribution and protein binding drug clearance drug metabolism and hepatic clearance pharmacokinetics after intravenous infusion pharmacokinetics after multiple dosing non-linear pharmacokinetics introduction to clinical pharmacokinetics application of pharmacokinetics to clinical situations relationship between pharmacokinetic parameters and pharmacologic response physiologic pharmacokinetic model and statistical moment computer applications in pharmacokinetics biopharmaceutics and pharmacokinetic studies in drug development appendix.
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Citations
Trichotomous gastric retention of amorphous capecitabine: an attempt to overcome pharmacokinetic gap.
TL;DR: Conclusively the employment of TRGDDS had extended the duration for which CAP stayed in the rodent model, providing evidence for potentially obtaining a more efficacious dosing regimen in actual disease models.
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Solubility enhancement methods with importance of hydrotropy
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TL;DR: The effectiveness of formulation depends particularly on how efficiently is drug available at the site of action as discussed by the authors, and the effectiveness depends on bioavailability and the solubility of drug moiety.
Pharmacokinetic profile of 2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucoside in mice after oral administration of Polygonum multiflorum extract.
TL;DR: This was the first report on determination of the pharmacokinetic profile of PM-SG in mice after oral administration and may provide a meaningful basis for evaluating the clinical applications of such a bioactive compound from herbal medicines.
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Safety pharmacology
Marta Luri
- 01 Jan 2022
TL;DR: In this article , the authors present early indicators of possible safety problems that are evident in early stage studies, such as cytotoxicity, off-target receptor effects, effects on the hERG potassium channel and mutagenicity.
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Stereospecific pharmacokinetics of racemic homoeriodictyol, isosakuranetin, and taxifolin in rats and their disposition in fruit
Karina R. Vega-Villa,Connie M. Remsberg,Jody K. Takemoto,Yusuke Ohgami,Jaime A. Yáñez,Preston K. Andrews,Neal M. Davies +6 more
TL;DR: The pharmacokinetics of homoeriodictyol, isosakuranetin, and taxifolin revealed distribution, metabolism, and elimination that were dependent on the stereochemistry of the stereoisomers.
17
References
Physiologically based pharmacokinetic modeling: Principles and applications
TL;DR: I was evaluated as a model organic anionic compound by characterizing the pharmacokinetics at three different doses and it was demonstrated that the biliary excretion of I depended on the amount present in the liver, and a saturable uptake process.
590
Bayesian Individualization of Pharmacokinetics: Simple Implementation and Comparison with Non-Bayesian Methods
Lewis B. Sheiner,Stuart L. Beal +1 more
TL;DR: In this report an implementation of the Bayesian method that is readily adapted to a microcomputer is presented and using simulated data it is compared with two other methods proposed by others, for estimating individual theophylline clearances.
299
General treatment of linear mammillary models with elimination from any compartment as used in pharmacokinetics.
TL;DR: This paper presents some very simplified general treatments which will allow workers to derive equations for any linear mammillary compartment model with any first- or zero-order or impulse input process through the use of general input and disposition functions, the method of partial fractions for solving Laplace transforms, and a multiple-dosing function.
212
Disposition kinetics of lidocaine in normal subjects
TL;DR: Results of the present study clarify the apparent discrepancies that exist between estimations of half-life based on clinical observation of pharmacologic effects of the drug and calculations made from limited clinical determinations.
208
Lidocaine disposition kinetics in monkey and man. II. Effects of hemorrhage and sympathomimetic drug administration.
TL;DR: A perfusion model that simulates blood and tissue levels during hemorrhage in monkey and man by using blood flow measurements during hemorrhagic shock is reported here and may be clinically useful in man simultaneously receiving a variety of cardioactive drugs ill suggesting appropriate ad;ustments of the dosages of the most critical drugs used.
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