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Applied biopharmaceutics and pharmacokinetics
Leon Shargel,Susanna Wu-Pong,Andrew B.C. Yu +2 more
- 01 Jan 1980
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TL;DR: Applied biopharmaceutics & pharmacokinetics, Applied biophARMaceutics and pharmacokinetic research, کتابخانه دیجیتال شاپور اهواز
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Abstract: Mathematical fundamentals on pharmacokinetics introduction to biopharmaceutics and pharmacokinetics one compartment model physiological factors relating to drug absorption biopharmaceutic considerations in drug product design modified release drug products delivery of biotechnical products and targetted drug delivery systems pharmacokinetics of drug absorption bioavailability and bioequivalence multicompartmental models drug distribution and protein binding drug clearance drug metabolism and hepatic clearance pharmacokinetics after intravenous infusion pharmacokinetics after multiple dosing non-linear pharmacokinetics introduction to clinical pharmacokinetics application of pharmacokinetics to clinical situations relationship between pharmacokinetic parameters and pharmacologic response physiologic pharmacokinetic model and statistical moment computer applications in pharmacokinetics biopharmaceutics and pharmacokinetic studies in drug development appendix.
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Citations
3D integration of pH-cleavable drug-hydrogel conjugates on magnetically driven smart microtransporters
Roberto Bernasconi,Emanuele Mauri,Emanuele Mauri,Arianna Rossetti,Stefano Rimondo,Raffaella Suriano,Marinella Levi,Alessandro Sacchetti,Salvador Pané,Luca Magagnin,Filippo Rossi +10 more
TL;DR: The coating of magnetically controlled microdevices with functionalized alginate-based hydrogels able to release drugs at pH values lower than 4.5 are described, which are particularly promising for in-vivo applications in environments where pH differences are present, like the digestive apparatus.
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Effects of fasting and gender on ochratoxin A toxicokinetics in F344 rats.
Ariane Vettorazzi,Iñaki F. Trocóniz,Elena González-Peñas,L.A. Corcuera,Leire Arbillaga,Ana Gloria Gil,Judit M. Nagy,Peter G. Mantle,A. López de Cerain +8 more
TL;DR: Evaluating two factors which could explain the different kinetic profile of OTA bioavailability in mature F344 male rats under fasting conditions: the presence of food and the male-specific protein alpha-2u-globulin.
20
Disposition of two highly permeable drugs in the upper gastrointestinal lumen of healthy adults after a standard high-calorie, high-fat meal.
TL;DR: Concentrations in the aqueous/micellar phase of luminal contents and values of parameters controlling the transfer from bulk gastric contents through the upper small intestine, after a high-calorie, high-fat meal, were reported for first time for highly permeable drugs.
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Preparation of biodegradable microcapsules containing zidovudine (AZT) using solvent evaporation technique.
TL;DR: The dissolution of AZT was dependent on the type of theCopolymer used and the relative concentrations of the drug and the copolymer.
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Intranasal delivery of a novel acetylcholinesterase inhibitor HLS-3 for treatment of Alzheimer's disease.
TL;DR: Intranasal delivery of HLS‐3 with better pharmacokinetics and pharmacodynamics performances provides a promising approach for treatment of Alzheimer's disease.
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References
Physiologically based pharmacokinetic modeling: Principles and applications
TL;DR: I was evaluated as a model organic anionic compound by characterizing the pharmacokinetics at three different doses and it was demonstrated that the biliary excretion of I depended on the amount present in the liver, and a saturable uptake process.
590
Bayesian Individualization of Pharmacokinetics: Simple Implementation and Comparison with Non-Bayesian Methods
Lewis B. Sheiner,Stuart L. Beal +1 more
TL;DR: In this report an implementation of the Bayesian method that is readily adapted to a microcomputer is presented and using simulated data it is compared with two other methods proposed by others, for estimating individual theophylline clearances.
299
General treatment of linear mammillary models with elimination from any compartment as used in pharmacokinetics.
TL;DR: This paper presents some very simplified general treatments which will allow workers to derive equations for any linear mammillary compartment model with any first- or zero-order or impulse input process through the use of general input and disposition functions, the method of partial fractions for solving Laplace transforms, and a multiple-dosing function.
212
Disposition kinetics of lidocaine in normal subjects
TL;DR: Results of the present study clarify the apparent discrepancies that exist between estimations of half-life based on clinical observation of pharmacologic effects of the drug and calculations made from limited clinical determinations.
208
Lidocaine disposition kinetics in monkey and man. II. Effects of hemorrhage and sympathomimetic drug administration.
TL;DR: A perfusion model that simulates blood and tissue levels during hemorrhage in monkey and man by using blood flow measurements during hemorrhagic shock is reported here and may be clinically useful in man simultaneously receiving a variety of cardioactive drugs ill suggesting appropriate ad;ustments of the dosages of the most critical drugs used.
130
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