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Applied biopharmaceutics and pharmacokinetics
Leon Shargel,Susanna Wu-Pong,Andrew B.C. Yu +2 more
- 01 Jan 1980
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TL;DR: Applied biopharmaceutics & pharmacokinetics, Applied biophARMaceutics and pharmacokinetic research, کتابخانه دیجیتال شاپور اهواز
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Abstract: Mathematical fundamentals on pharmacokinetics introduction to biopharmaceutics and pharmacokinetics one compartment model physiological factors relating to drug absorption biopharmaceutic considerations in drug product design modified release drug products delivery of biotechnical products and targetted drug delivery systems pharmacokinetics of drug absorption bioavailability and bioequivalence multicompartmental models drug distribution and protein binding drug clearance drug metabolism and hepatic clearance pharmacokinetics after intravenous infusion pharmacokinetics after multiple dosing non-linear pharmacokinetics introduction to clinical pharmacokinetics application of pharmacokinetics to clinical situations relationship between pharmacokinetic parameters and pharmacologic response physiologic pharmacokinetic model and statistical moment computer applications in pharmacokinetics biopharmaceutics and pharmacokinetic studies in drug development appendix.
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Citations
Chitosan/pectin polyelectrolyte complexes: selection of suitable preparative conditions for colon-specific delivery of vancomycin.
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Effects of liver disease on pharmacokinetics : An update
TL;DR: This review updates recent developments in CYP, with particular emphasis on cytochrome P450, a rapidly expanding area in clinical pharmacology, and examines drugs with altered pharmacodynamics.
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Interaction of mitoxantrone with human serum albumin: spectroscopic and molecular modeling studies.
Shahper N. Khan,Barira Islam,Ragothaman M. Yennamalli,Abdullah Sultan,Naidu Subbarao,Asad U. Khan +5 more
TL;DR: Molecular docking showed that the MTX binds HSA to a non-classical drug binding site and synchronous fluorescence, thermodynamic parameters and molecular modeling, which entails that hydrophobic interactions, hydrogen bonding and electrostatic forces, stabilizes the interaction.
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Direct Olfactory Transport of Inhaled Manganese (54MnCl2) to the Rat Brain: Toxicokinetic Investigations in a Unilateral Nasal Occlusion Model
Karrie A. Brenneman,Brian A. Wong,Matthew A. Buccellato,Elisabeth R. Costa,Elizabeth A. Gross,David C. Dorman +5 more
TL;DR: It is demonstrated, for the first time, that the olfactory route contributes the majority (up to >90%) of the (54)Mn found in the Olfactory pathway, but not in the striatum, of the rat brain up to 8 days following a single inhalation exposure.
204
Multi-ion-crosslinked nanoparticles with pH-responsive characteristics for oral delivery of protein drugs
Yu Hsin Lin,Kiran Sonaje,Kurt M. Lin,Jyuhn Huarng Juang,Fwu Long Mi,Han Wen Yang,Hsing-Wen Sung +6 more
TL;DR: The results suggest that multi-ion-crosslinked NPs are a promising carrier for improved transmucosal delivery of insulin in the small intestine.
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References
Physiologically based pharmacokinetic modeling: Principles and applications
TL;DR: I was evaluated as a model organic anionic compound by characterizing the pharmacokinetics at three different doses and it was demonstrated that the biliary excretion of I depended on the amount present in the liver, and a saturable uptake process.
590
Bayesian Individualization of Pharmacokinetics: Simple Implementation and Comparison with Non-Bayesian Methods
Lewis B. Sheiner,Stuart L. Beal +1 more
TL;DR: In this report an implementation of the Bayesian method that is readily adapted to a microcomputer is presented and using simulated data it is compared with two other methods proposed by others, for estimating individual theophylline clearances.
299
General treatment of linear mammillary models with elimination from any compartment as used in pharmacokinetics.
TL;DR: This paper presents some very simplified general treatments which will allow workers to derive equations for any linear mammillary compartment model with any first- or zero-order or impulse input process through the use of general input and disposition functions, the method of partial fractions for solving Laplace transforms, and a multiple-dosing function.
212
Disposition kinetics of lidocaine in normal subjects
TL;DR: Results of the present study clarify the apparent discrepancies that exist between estimations of half-life based on clinical observation of pharmacologic effects of the drug and calculations made from limited clinical determinations.
208
Lidocaine disposition kinetics in monkey and man. II. Effects of hemorrhage and sympathomimetic drug administration.
TL;DR: A perfusion model that simulates blood and tissue levels during hemorrhage in monkey and man by using blood flow measurements during hemorrhagic shock is reported here and may be clinically useful in man simultaneously receiving a variety of cardioactive drugs ill suggesting appropriate ad;ustments of the dosages of the most critical drugs used.
130
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