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Applied biopharmaceutics and pharmacokinetics
Leon Shargel,Susanna Wu-Pong,Andrew B.C. Yu +2 more
- 01 Jan 1980
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TL;DR: Applied biopharmaceutics & pharmacokinetics, Applied biophARMaceutics and pharmacokinetic research, کتابخانه دیجیتال شاپور اهواز
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Abstract: Mathematical fundamentals on pharmacokinetics introduction to biopharmaceutics and pharmacokinetics one compartment model physiological factors relating to drug absorption biopharmaceutic considerations in drug product design modified release drug products delivery of biotechnical products and targetted drug delivery systems pharmacokinetics of drug absorption bioavailability and bioequivalence multicompartmental models drug distribution and protein binding drug clearance drug metabolism and hepatic clearance pharmacokinetics after intravenous infusion pharmacokinetics after multiple dosing non-linear pharmacokinetics introduction to clinical pharmacokinetics application of pharmacokinetics to clinical situations relationship between pharmacokinetic parameters and pharmacologic response physiologic pharmacokinetic model and statistical moment computer applications in pharmacokinetics biopharmaceutics and pharmacokinetic studies in drug development appendix.
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Citations
Monoclonal anti-leukemia inhibitory factor antibody inhibits blastocyst implantation in the rhesus monkey
TL;DR: The results of the present study put forward the proof of concept that LIF plays a critical role in the process of blastocyst implantation in the rhesus monkey.
38
Kidney and liver distribution of ochratoxin A in male and female F344 rats.
Ariane Vettorazzi,Iñaki F. Trocóniz,Elena González-Peñas,Leire Arbillaga,L.A. Corcuera,Ana Gloria Gil,Adela López de Cerain +6 more
TL;DR: The sex differences observed in organs distribution are a reflection of the differences in relative bioavailability observed in adult males, as a consequence of the fed and fasted conditions and to the significant higher body weight of mature males which directly affected the V/F and V(L,K)/F.
38
Bioavailability of riboflavin from a gastric retention formulation
Iman S. Ahmed,James W. Ayres +1 more
TL;DR: It was found that when the GRF is dried and immersed in gastric juice it swells rapidly and releases its drug content in a zero-order fashion for a period of 24 h, and bioavailability of riboflavin from a large size GRF was more than triple that measured after administration of an immediate release formulation.
37
Drug-drug interactions involving lysosomes: mechanisms and potential clinical implications
TL;DR: It is proposed that drug-drug interactions involving lysosomes represent an important potential source of variability in drug activity and pharmacokinetics and is needed to fully explore the impact of this drug- drug interaction pathway on therapeutic outcomes.
37
References
Physiologically based pharmacokinetic modeling: Principles and applications
TL;DR: I was evaluated as a model organic anionic compound by characterizing the pharmacokinetics at three different doses and it was demonstrated that the biliary excretion of I depended on the amount present in the liver, and a saturable uptake process.
590
Bayesian Individualization of Pharmacokinetics: Simple Implementation and Comparison with Non-Bayesian Methods
Lewis B. Sheiner,Stuart L. Beal +1 more
TL;DR: In this report an implementation of the Bayesian method that is readily adapted to a microcomputer is presented and using simulated data it is compared with two other methods proposed by others, for estimating individual theophylline clearances.
299
General treatment of linear mammillary models with elimination from any compartment as used in pharmacokinetics.
TL;DR: This paper presents some very simplified general treatments which will allow workers to derive equations for any linear mammillary compartment model with any first- or zero-order or impulse input process through the use of general input and disposition functions, the method of partial fractions for solving Laplace transforms, and a multiple-dosing function.
212
Disposition kinetics of lidocaine in normal subjects
TL;DR: Results of the present study clarify the apparent discrepancies that exist between estimations of half-life based on clinical observation of pharmacologic effects of the drug and calculations made from limited clinical determinations.
208
Lidocaine disposition kinetics in monkey and man. II. Effects of hemorrhage and sympathomimetic drug administration.
TL;DR: A perfusion model that simulates blood and tissue levels during hemorrhage in monkey and man by using blood flow measurements during hemorrhagic shock is reported here and may be clinically useful in man simultaneously receiving a variety of cardioactive drugs ill suggesting appropriate ad;ustments of the dosages of the most critical drugs used.
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