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Applied biopharmaceutics and pharmacokinetics
Leon Shargel,Susanna Wu-Pong,Andrew B.C. Yu +2 more
- 01 Jan 1980
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TL;DR: Applied biopharmaceutics & pharmacokinetics, Applied biophARMaceutics and pharmacokinetic research, کتابخانه دیجیتال شاپور اهواز
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Abstract: Mathematical fundamentals on pharmacokinetics introduction to biopharmaceutics and pharmacokinetics one compartment model physiological factors relating to drug absorption biopharmaceutic considerations in drug product design modified release drug products delivery of biotechnical products and targetted drug delivery systems pharmacokinetics of drug absorption bioavailability and bioequivalence multicompartmental models drug distribution and protein binding drug clearance drug metabolism and hepatic clearance pharmacokinetics after intravenous infusion pharmacokinetics after multiple dosing non-linear pharmacokinetics introduction to clinical pharmacokinetics application of pharmacokinetics to clinical situations relationship between pharmacokinetic parameters and pharmacologic response physiologic pharmacokinetic model and statistical moment computer applications in pharmacokinetics biopharmaceutics and pharmacokinetic studies in drug development appendix.
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Citations
A review on bioavailability enhancers of herbal origin
D Jo
- 01 Jan 2014
TL;DR: Oral absorption of vitamins, minerals, herbal extracts, amino acids and other nutrients are improved by phytomolecules development, which act through several mechanisms which may affect mainly absorption process, drug metabolism or action on drug-target.
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Qualitative and Quantitative investigations of Furocoumarin derivatives (Psoralens) of Haplophyllum tuberculatum (Rutaceae)
Arif Diar,Jawad Enas,Al-Khateeb Ekbal,Al-shamma Ali +3 more
- 01 Jan 2005
TL;DR: In this paper, a preliminary investigation of the furocoumarins content of Haplophyllum tuberculatum has been carried out and the results were discussed and the extraction procedure of the plant material, the fractionation and isolation procedures of the FURCOUMARINs are fully described.
6
A technical note concerning non-adherence to drug therapy: exact expressions for the mean and variance of drug concentration
Steve Gallivan,Christina Pagel,Martin Utley,Bryony Dean Franklin,Bryony Dean Franklin,Katja Taxis,Nick Barber +6 more
TL;DR: A stochastic pharmacokinetic mathematical model is presented that can be used to assess the implications of non-adherence to prescribed drug regimens, on the part of either patients or health professionals, and can be adapted for use in the context of other routes of drug administration.
Bioanalytical evaluation of dried plasma spot microsampling methodologies in pharmacokinetic studies applying Acetaminophen as model drug
TL;DR: Dried plasma spot bioassays could have a great potential as alternative sampling technique in pharmacokinetic studies and be validated as well as working well and not statistically significant different from values reported in literature.
6
References
Physiologically based pharmacokinetic modeling: Principles and applications
TL;DR: I was evaluated as a model organic anionic compound by characterizing the pharmacokinetics at three different doses and it was demonstrated that the biliary excretion of I depended on the amount present in the liver, and a saturable uptake process.
590
Bayesian Individualization of Pharmacokinetics: Simple Implementation and Comparison with Non-Bayesian Methods
Lewis B. Sheiner,Stuart L. Beal +1 more
TL;DR: In this report an implementation of the Bayesian method that is readily adapted to a microcomputer is presented and using simulated data it is compared with two other methods proposed by others, for estimating individual theophylline clearances.
299
General treatment of linear mammillary models with elimination from any compartment as used in pharmacokinetics.
TL;DR: This paper presents some very simplified general treatments which will allow workers to derive equations for any linear mammillary compartment model with any first- or zero-order or impulse input process through the use of general input and disposition functions, the method of partial fractions for solving Laplace transforms, and a multiple-dosing function.
212
Disposition kinetics of lidocaine in normal subjects
TL;DR: Results of the present study clarify the apparent discrepancies that exist between estimations of half-life based on clinical observation of pharmacologic effects of the drug and calculations made from limited clinical determinations.
208
Lidocaine disposition kinetics in monkey and man. II. Effects of hemorrhage and sympathomimetic drug administration.
TL;DR: A perfusion model that simulates blood and tissue levels during hemorrhage in monkey and man by using blood flow measurements during hemorrhagic shock is reported here and may be clinically useful in man simultaneously receiving a variety of cardioactive drugs ill suggesting appropriate ad;ustments of the dosages of the most critical drugs used.
130
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