Application of Cornelian Cherry Iridoid-Polyphenolic Fraction and Loganic Acid to Reduce Intraocular Pressure
Dorota Szumny,Tomasz Sozański,Alicja Z. Kucharska,Wojciech Dziewiszek,Narcyz Piórecki,Jan Magdalan,Ewa Chlebda-Sieragowska,Robert Kupczyński,Adam Szeląg,Antoni Szumny +9 more
TL;DR: A strong IOP-hypotensive effect for a 0.7% solution of loganic acid is found, which could be compared with the widely ophthalmologically used timolol, and about a 25% decrease in IOP was observed within the first 3 hours of use.
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Abstract: One of the most common diseases of old age in modern societies is glaucoma. It is strongly connected with increased intraocular pressure (IOP) and could permanently damage vision in the affected eye. As there are only a limited number of chemical compounds that can decrease IOP as well as blood flow in eye vessels, the up-to-date investigation of new molecules is important. The chemical composition of the dried Cornelian cherry (Cornus mas L.) polar, iridoid-polyphenol-rich fraction was investigated. Loganic acid (50%) and pelargonidin-3-galactoside (7%) were found as the main components. Among the other constituents, iridoid compound cornuside and the anthocyans cyanidin 3-O-galactoside, cyanidin 3-O-robinobioside, and pelargonidin 3-O-robinobioside were quantified in the fraction. In an animal model (New Zealand rabbits), the influence of loganic acid and the polyphenolic fraction isolated from Cornelian cherry fruit was investigated. We found a strong IOP-hypotensive effect for a 0.7% solution of loganic acid, which could be compared with the widely ophthalmologically used timolol. About a 25% decrease in IOP was observed within the first 3 hours of use.
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Citations
Health Benefits of Polyphenols and Carotenoids in Age-Related Eye Diseases
Simona Bungau,Mohamed M. Abdel-Daim,Mohamed M. Abdel-Daim,Delia Mirela Tit,Esraa Ghanem,Shimpei Sato,Maiko Maruyama-Inoue,Shin Yamane,Kazuaki Kadonosono +8 more
TL;DR: The role and mechanisms of polyphenols and carotenoids and their possible synergistic effects on the prevention and treatment of age-related eye diseases that are induced or augmented by oxidative stress and inflammation are discussed.
Cornus mas L. (cornelian cherry), an important European and Asian traditional food and medicine: Ethnomedicine, phytochemistry and pharmacology for its commercial utilization in drug industry.
Biswanath Dinda,Anthony M. Kyriakopoulos,Subhajit Dinda,Vassilis Zoumpourlis,Nikolaos S. Thomaidis,Aristea Velegraki,Charlambos Markopoulos,Manikarna Dinda +7 more
TL;DR: Fruits of Cornus mas L. (cornelian cherry) are a potential source for treatment of diabetes, obesity, hyperlipidemia and gastrointestinal disorders and are non-toxic and safe food on acute toxicity studies in rat and human models.
151
Antioxidant activity of Cornelian cherry (Cornus mas L.) fruits extract and the in vivo evaluation of its anti-inflammatory effects
Bianca Moldovan,Adriana Filip,Simona Clichici,Ramona Suharoschi,Pompei Bolfa,Pompei Bolfa,Luminita David +6 more
TL;DR: In this article, the biological activity of Cornus mas fruits (CM) on acute inflammation in relation to the in vitro antioxidant properties was investigated, and the in-vivo antioxidant activity was evaluated by ferric reducing ability of plasma (FRAP) and by 2,2′-azinobis-3-ethyl-benzthiazino-6-sulphonic acid (ABTS) test.
100
Cornus mas and Cornus Officinalis—Analogies and Differences of Two Medicinal Plants Traditionally Used
TL;DR: Comparison of phytochemical composition of fruits from both species revealed a wide range of similarities as well as some constituents unique for cornelian cherry or Asiatic dogwood.
Functional properties of Cornelian cherry (Cornus mas L.): a comprehensive review
TL;DR: The results of current studies including their synthesis are presented to answer the question whether the Cornelian cherry exhibits positive properties due to its bioactive compound content.
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