Journal Article10.3109/10799899109066412
Appearance and transient expression of vasopressin and oxytocin receptors in the rat brain.
Eliane Tribollet,Michel Goumaz,Mario Raggenbass,Jean-Jacques Dreifuss +3 more
- 01 Jan 1991
- Vol. 11, pp 333-346
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TL;DR: Electrophysiological studies suggest that at least some of these "transient" binding sites for AVP and OT represent authentic receptors and may be involved in neuronal signaling.
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Abstract: Binding sites for AVP and for OT were studied by in vitro autoradiography in sections from the brain of rat fetuses, neonates and infants; their distribution was compared to that of the brain of adults. Specific binding sites were first detected in the vagal complex for OT and in the reticular formation for AVP at E14 and E16 respectively. In the perinatal period, other areas become labeled. Approximately one week after birth, a "stable" pattern of distribution is established for AVP binding sites, and a different "stable" pattern obtained for OT binding sites. For both types of sites and in many areas, the density of labeling increases during the next two weeks to reach adult levels, whereas labeling decreases concomitantly in other areas of the brain. The distribution of AVP binding sites is of the adult pattern by the time of weaning. In contrast, the adult pattern of distribution of OT binding sites is only established after puberty, when new OT receptors appear in some regions of the hypothalamus and basal forebrain. "Transient" binding sites for AVP and OT, i.e. sites located in areas which were labeled in neonates but not in weanlings, were shown to have the same ligand affinity than the binding sites present in the adult. Electrophysiological studies suggest that at least some of these "transient" binding sites represent authentic receptors and may be involved in neuronal signaling.
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Pathophysiology of Sleep Apnea
TL;DR: This work reviews three types of major long-term sequelae to severe OSA and discusses future research into understanding the pathophysiology of sleep apnea as a basis for uncovering newer forms of treatment of both the ventilatory disorder and its multiple sequelae.
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Vasopressin and oxytocin receptor systems in the brain: Sex differences and sex-specific regulation of social behavior.
Kelly M. Dumais,Alexa H. Veenema +1 more
TL;DR: This review discusses the evidence showing the presence or absence of sex differences in VP and OT receptors in rodents and humans, as well as showing new data of sexually dimorphic V1a receptor binding in the rat brain.
462
Association of the oxytocin receptor gene (OXTR) in Caucasian children and adolescents with autism.
TL;DR: Support is provided for association of OXTR with autism in a Caucasian population by overtransmission of the G allele to probands with autistic disorder and the haplotype test of association did not reveal excess transmission from parents to affected offspring.
448
Oxytocin and Vasopressin Agonists and Antagonists as Research Tools and Potential Therapeutics
Maurice Manning,Aleksandra Misicka,Aleksandra Misicka,Aleksandra Olma,Aleksandra Olma,K. Bankowski,Stoytcho Stoev,Bice Chini,Thierry Durroux,Bernard Mouillac,Maithé Corbani,Gilles Guillon +11 more
TL;DR: The status of peptide and non-peptide agonists and antagonists for the V1a, V1b and V2 receptors for arginine vasopressin (AVP) and the O2 receptor for oxytocin (OT) was reviewed in this paper.
Transgenerational effects of social environment on variations in maternal care and behavioral response to novelty.
TL;DR: Maternal LG and the neural mechanisms that regulate this behavior exhibited a high degree of plasticity in response to changes in environment both within and beyond the postnatal period, with implications for the transmission of behavioral response to novelty and maternal care across generations.
371
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TL;DR: This paper presents a meta-analyses of the determinants of earthquake-triggered landsliding in the Czech Republic over a period of 18 months in order to establish a probabilistic framework for estimating the intensity of the earthquake.
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125I-labelled d(CH2)5[Tyr(Me)2,Thr4,Tyr-NH29]OVT: a selective oxytocin receptor ligand
J. Elands,Claude Barberis,Serge Jard,Eliane Tribollet,Jean-Jacques Dreifuss,Krzysztof Bankowski,Maurice Manning,Wilbur H. Sawyer +7 more
TL;DR: 125I-labelled d(CH2)5[Tyr(Me)2,Thr4,Tyr-NH2(9)]OVT [corrected] was demonstrated to bind selectively to one population of binding sites in rat uterus and ventral hippocampal membrane preparations, allowing important reductions in membrane protein amount, gain in precision of binding analysis as well as considerably lower exposure times for autoradiography.
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Pharmacological characterization of two specific binding sites for neurohypophyseal hormones in hippocampal synaptic plasma membranes of the rat.
S Audigier,C Barberis +1 more
TL;DR: The specificity of these binding sites, tested in competition experiments, revealed that these neurohypophyseal hormones labelled two distinct populations of sites, one population with a high affinity for vasopressin, oxytocin and vasotocin and a low affinity for oxytoc in comparison with previously characterized peripheral receptors.
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Synthesis and some pharmacological properties of [4-threonine, 7-glycine]oxytocin, [1-(L-2-hydroxy-3-mercaptopropanoic acid), 4-threonine, 7-glycine]oxytocin (hydroxy[Thr4, Gly7]oxytocin), and [7-Glycine]oxytocin, peptides with high oxytocic-antidiuretic selectivity.
TL;DR: Threonine substitution has brought about a substantial enhancement in oxytocic activity and a fivefold enhancement in O/A selectivity in these peptides, which might offer a greater margin of safety than oxytocin in those clinical stiuations in which the latter is currently employed.
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A role of central oxytocin in autonomic functions: its action in the motor nucleus of the vagus nerve.
TL;DR: Results suggest a role for central oxytocin in autonomic efferent activity and show that oxytocIn antagonist microinjected into the dorsal motor nucleus of the vagus nerve blocks gastric and cardiac effects caused by stimulation of the hypothalamic paraventricular nucleus.
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